| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tissue factor |
|---|
| Ligand | BDBM50293370 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_572140 (CHEMBL1024282) |
|---|
| IC50 | 233000±n/a nM |
|---|
| Citation |  Ayral, E; Gloanec, P; Bergé, G; de Nanteuil, G; Mennecier, P; Rupin, A; Verbeuren, TJ; Fulcrand, P; Martinez, J; Hernandez, JF Design, synthesis, and biological evaluation of 1,5-benzothiazepine-4-one derivatives targeting factor VIIa/tissue factor. Bioorg Med Chem Lett19:1386-91 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tissue factor |
|---|
| Name: | Tissue factor |
|---|
| Synonyms: | CD_antigen=CD142 | Coagulation factor III | Coagulation factor VII/tissue factor | F3 | TF | TF_HUMAN | Thromboplastin | Tissue factor |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 33067.61 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_936735 |
|---|
| Residue: | 295 |
|---|
| Sequence: | METPAWPRVPRPETAVARTLLLGWVFAQVAGASGTTNTVAAYNLTWKSTNFKTILEWEPK
PVNQVYTVQISTKSGDWKSKCFYTTDTECDLTDEIVKDVKQTYLARVFSYPAGNVESTGS
AGEPLYENSPEFTPYLETNLGQPTIQSFEQVGTKVNVTVEDERTLVRRNNTFLSLRDVFG
KDLIYTLYYWKSSSSGKKTAKTNTNEFLIDVDKGENYCFSVQAVIPSRTVNRKSTDSPVE
CMGQEKGEFREIFYIIGAVVFVVIILVIILAISLHKCRKAGVGQSWKENSPLNVS
|
|
|
|---|
| BDBM50293370 |
|---|
| n/a |
|---|
| Name | BDBM50293370 |
|---|
| Synonyms: | (S)-3-(3-acetamido-4-oxo-3,4-dihydrobenzo[b][1,4]thiazepin-5(2H)-yl)-N-(4-carbamimidoylbenzyl)propanamide, trifluoroacetate | CHEMBL557884 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H25N5O3S |
|---|
| Mol. Mass. | 439.531 |
|---|
| SMILES | CC(=O)N[C@@H]1CSc2ccccc2N(CCC(=O)NCc2ccc(cc2)C(N)=N)C1=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
