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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Sodium- and chloride-dependent glycine transporter 1 | ||
| Ligand | BDBM50293568 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_570823 (CHEMBL792716) | ||
| Ki | 1.8±n/a nM | ||
| Citation |  Lowe, JA; Hou, X; Schmidt, C; David Tingley, F; McHardy, S; Kalman, M; Deninno, S; Sanner, M; Ward, K; Lebel, L; Tunucci, D; Valentine, J; Bronk, BS; Schaeffer, E The discovery of a structurally novel class of inhibitors of the type 1 glycine transporter. Bioorg Med Chem Lett19:2974-6 (2009) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Sodium- and chloride-dependent glycine transporter 1 | |||
| Name: | Sodium- and chloride-dependent glycine transporter 1 | ||
| Synonyms: | GlyT-1 | GlyT1 | Glycine Transporters (GlyT1c) | Glycine transporter 1 | SC6A9_HUMAN | SLC6A9 | Sodium- and chloride-dependent glycine transporter 1 | Sodium- and chloride-dependent glycine transporter 1 (GlyT1) | Sodium- and chloride-dependent glycine transporter 1 (GlyT1c) | Sodium-and chloride-dependent glycine transporter 1 (GlyT-1c) | Solute carrier family 6 member 9 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 78270.54 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P48067 | ||
| Residue: | 706 | ||
| Sequence: |
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| BDBM50293568 | |||
| n/a | |||
| Name | BDBM50293568 | ||
| Synonyms: | CHEMBL563761 | Cis-N-(3-Chlorobenzyl)-N-(-4-aminocyclohexyl)-1-methyl-1H-imidazole-4-carboxamide | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H23ClN4O | ||
| Mol. Mass. | 346.854 | ||
| SMILES | Cn1cnc(c1)C(=O)N(Cc1cccc(Cl)c1)[C@@H]1CC[C@H](N)CC1 |r,wU:17.18,20.22,(3.36,-16.16,;4.05,-14.78,;3.34,-13.41,;4.42,-12.32,;5.8,-13.01,;5.57,-14.53,;7.16,-12.3,;7.23,-10.76,;8.46,-13.13,;9.83,-12.42,;11.12,-13.25,;11.05,-14.78,;12.34,-15.61,;13.71,-14.9,;13.78,-13.36,;15.14,-12.64,;12.48,-12.54,;8.39,-14.67,;7.02,-15.37,;6.95,-16.9,;8.24,-17.73,;8.16,-19.27,;9.61,-17.03,;9.69,-15.48,)| | ||
| Structure | 
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