Reaction Details |
| Report a problem with these data |
Target | Aurora kinase B |
---|
Ligand | BDBM50293669 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_571640 (CHEMBL1031295) |
---|
Ki | 51±n/a nM |
---|
Citation | Bebbington, D; Binch, H; Charrier, JD; Everitt, S; Fraysse, D; Golec, J; Kay, D; Knegtel, R; Mak, C; Mazzei, F; Miller, A; Mortimore, M; O'Donnell, M; Patel, S; Pierard, F; Pinder, J; Pollard, J; Ramaya, S; Robinson, D; Rutherford, A; Studley, J; Westcott, J The discovery of the potent aurora inhibitor MK-0457 (VX-680). Bioorg Med Chem Lett19:3586-92 (2009) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Aurora kinase B |
---|
Name: | Aurora kinase B |
Synonyms: | AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B |
Type: | Protein |
Mol. Mass.: | 39327.72 |
Organism: | Homo sapiens (Human) |
Description: | Q96GD4 |
Residue: | 344 |
Sequence: | MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
|
|
|
BDBM50293669 |
---|
n/a |
---|
Name | BDBM50293669 |
Synonyms: | CHEMBL564449 | N-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)quinazolin-2-ylthio)phenyl)cyclopropanecarboxamide |
Type | Small organic molecule |
Emp. Form. | C22H20N6OS |
Mol. Mass. | 416.499 |
SMILES | Cc1cc(Nc2nc(Sc3ccc(NC(=O)C4CC4)cc3)nc3ccccc23)[nH]n1 |
Structure |
|