Reaction Details |
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Target | Matrix metalloproteinase-9 |
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Ligand | BDBM50294124 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_571085 (CHEMBL812786) |
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IC50 | 1100±n/a nM |
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Citation | Nuti, E; Casalini, F; Avramova, SI; Santamaria, S; Cercignani, G; Marinelli, L; La Pietra, V; Novellino, E; Orlandini, E; Nencetti, S; Tuccinardi, T; Martinelli, A; Lim, NH; Visse, R; Nagase, H; Rossello, A N-O-isopropyl sulfonamido-based hydroxamates: design, synthesis and biological evaluation of selective matrix metalloproteinase-13 inhibitors as potential therapeutic agents for osteoarthritis. J Med Chem52:4757-73 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Matrix metalloproteinase-9 |
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Name: | Matrix metalloproteinase-9 |
Synonyms: | 67 kDa matrix metalloproteinase-9 | 82 kDa matrix metalloproteinase-9 | 92 kDa gelatinase | 92 kDa type IV collagenase | CLG4B | GELB | Gelatinase B | MMP-9 | MMP9 | MMP9_HUMAN | Matrix metalloproteinase 9 (MMP-9) | Matrix metalloproteinase-9 (MMP-9) | Matrix metalloproteinase-9 (MMP9) |
Type: | Enzyme |
Mol. Mass.: | 78452.28 |
Organism: | Homo sapiens (Human) |
Description: | P14780 |
Residue: | 707 |
Sequence: | MSLWQPLVLVLLVLGCCFAAPRQRQSTLVLFPGDLRTNLTDRQLAEEYLYRYGYTRVAEM
RGESKSLGPALLLLQKQLSLPETGELDSATLKAMRTPRCGVPDLGRFQTFEGDLKWHHHN
ITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYP
FDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVVVPTRFGNADGAACHFPFIFEGRS
YSACTTDGRSDGLPWCSTTANYDTDDRFGFCPSERLYTQDGNADGKPCQFPFIFQGQSYS
ACTTDGRSDGYRWCATTANYDRDKLFGFCPTRADSTVMGGNSAGELCVFPFTFLGKEYST
CTSEGRGDGRLWCATTSNFDSDKKWGFCPDQGYSLFLVAAHEFGHALGLDHSSVPEALMY
PMYRFTEGPPLHKDDVNGIRHLYGPRPEPEPRPPTTTTPQPTAPPTVCPTGPPTVHPSER
PTAGPTGPPSAGPTGPPTAGPSTATTVPLSPVDDACNVNIFDAIAEIGNQLYLFKDGKYW
RFSEGRGSRPQGPFLIADKWPALPRKLDSVFEERLSKKLFFFSGRQVWVYTGASVLGPRR
LDKLGLGADVAQVTGALRSGRGKMLLFSGRRLWRFDVKAQMVDPRSASEVDRMFPGVPLD
THDVFQYREKAYFCQDRFYWRVSSRSELNQVDQVGYVTYDILQCPED
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BDBM50294124 |
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n/a |
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Name | BDBM50294124 |
Synonyms: | 2-(4'-(4-Chlorobenzyloxy)-N-isopropoxybiphenyl-4-ylsulfonamido)-N-hydroxyacetamide | CHEMBL550350 |
Type | Small organic molecule |
Emp. Form. | C24H25ClN2O6S |
Mol. Mass. | 504.983 |
SMILES | CC(C)ON(CC(=O)NO)S(=O)(=O)c1ccc(cc1)-c1ccc(OCc2ccc(Cl)cc2)cc1 |
Structure |
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