Reaction Details |
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Target | Stromelysin-1 |
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Ligand | BDBM50294124 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_571083 (CHEMBL812784) |
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IC50 | 1800±n/a nM |
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Citation | Nuti, E; Casalini, F; Avramova, SI; Santamaria, S; Cercignani, G; Marinelli, L; La Pietra, V; Novellino, E; Orlandini, E; Nencetti, S; Tuccinardi, T; Martinelli, A; Lim, NH; Visse, R; Nagase, H; Rossello, A N-O-isopropyl sulfonamido-based hydroxamates: design, synthesis and biological evaluation of selective matrix metalloproteinase-13 inhibitors as potential therapeutic agents for osteoarthritis. J Med Chem52:4757-73 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Stromelysin-1 |
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Name: | Stromelysin-1 |
Synonyms: | MMP-3 | MMP3 | MMP3_HUMAN | Matrix metalloproteinase (2 and 3) | Matrix metalloproteinase 3 | Matrix metalloproteinase-3 | Matrix metalloproteinase-3 (MMP-3) | Matrix metalloproteinase-3 (MMP3) | SL-1 | STMY1 | Stromelysin 1 | Transin-1 |
Type: | Enzyme |
Mol. Mass.: | 53973.13 |
Organism: | Homo sapiens (Human) |
Description: | P08254 |
Residue: | 477 |
Sequence: | MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPV
VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVN
YTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNV
LAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLY
HSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVS
TLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQF
WAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEP
GFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
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BDBM50294124 |
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n/a |
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Name | BDBM50294124 |
Synonyms: | 2-(4'-(4-Chlorobenzyloxy)-N-isopropoxybiphenyl-4-ylsulfonamido)-N-hydroxyacetamide | CHEMBL550350 |
Type | Small organic molecule |
Emp. Form. | C24H25ClN2O6S |
Mol. Mass. | 504.983 |
SMILES | CC(C)ON(CC(=O)NO)S(=O)(=O)c1ccc(cc1)-c1ccc(OCc2ccc(Cl)cc2)cc1 |
Structure |
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