Reaction Details |
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Target | Eukaryotic translation initiation factor 4E |
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Ligand | BDBM50294221 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_574910 (CHEMBL1023607) |
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Ki | 4100±n/a nM |
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Citation | Kowalska, J; Lukaszewicz, M; Zuberek, J; Ziemniak, M; Darzynkiewicz, E; Jemielity, J Phosphorothioate analogs of m7GTP are enzymatically stable inhibitors of cap-dependent translation. Bioorg Med Chem Lett19:1921-5 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Eukaryotic translation initiation factor 4E |
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Name: | Eukaryotic translation initiation factor 4E |
Synonyms: | EIF4E | IF4E_RABIT |
Type: | PROTEIN |
Mol. Mass.: | 25047.40 |
Organism: | Oryctolagus cuniculus |
Description: | ChEMBL_1511842 |
Residue: | 217 |
Sequence: | MATVEPETTPTPNPPPAEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANL
RLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQ
QRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENRDAVTHIG
RVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
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BDBM50294221 |
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n/a |
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Name | BDBM50294221 |
Synonyms: | 2-amino-9-[(2R,3R,4S,5R)-5-{[({[({[(2R,3S,4R,5R)-5-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphonato}oxy)phosphinato]oxy}(sulfanidyl)phosphoryl)oxy]methyl}-3,4-dihydroxyoxolan-2-yl]-7-methyl-6-oxido-9H-purin-7-ium | CHEMBL555980 |
Type | Small organic molecule |
Emp. Form. | C21H26N10O17P3S |
Mol. Mass. | 815.476 |
SMILES | C[n+]1cn([C@@H]2O[C@H](CO[P@@]([S-])(=O)OP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c3nc(N)[nH]c4=O)[C@@H](O)[C@H]2O)c2nc(N)[n-]c(=O)c12 |r| |
Structure |
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