Reaction Details |
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Target | Sodium-dependent noradrenaline transporter |
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Ligand | BDBM50294271 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_575205 (CHEMBL1024552) |
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IC50 | 14.0±n/a nM |
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Citation | Fish, PV; Andrews, MD; Jonathan Fray, M; Stobie, A; Wakenhut, F; Whitlock, GA 4-Piperidines and 3-pyrrolidines as dual serotonin and noradrenaline reuptake inhibitors: design, synthesis and structure-activity relationships. Bioorg Med Chem Lett19:2829-34 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium-dependent noradrenaline transporter |
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Name: | Sodium-dependent noradrenaline transporter |
Synonyms: | Monoamine transporter | NAT1 | NET | NET1 | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SC6A2_HUMAN | SLC6A2 | SLC6A5 | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2 |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 69337.72 |
Organism: | Homo sapiens (Human) |
Description: | P23975 |
Residue: | 617 |
Sequence: | MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG
KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW
NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA
IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL
VAQRDIRQFQLQHWLAI
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BDBM50294271 |
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n/a |
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Name | BDBM50294271 |
Synonyms: | 5-((2,3-dichlorophenoxy)(piperidin-4-yl)methyl)-2-methyl pyridine | 5-((2,3-dichlorophenoxy)(piperidin-4-yl)methyl)-2-methylpyridine | CHEMBL559081 | rac-3-((2,3-dichloro-6-methylphenoxy)(piperidin-4-yl)methyl)pyridine |
Type | Small organic molecule |
Emp. Form. | C18H20Cl2N2O |
Mol. Mass. | 351.27 |
SMILES | Cc1ccc(cn1)C(Oc1cccc(Cl)c1Cl)C1CCNCC1 |
Structure |
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