| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 2D6 |
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| Ligand | BDBM50294270 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_575311 (CHEMBL1023618) |
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| IC50 | 20000±n/a nM |
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| Citation |  Fish, PV; Andrews, MD; Jonathan Fray, M; Stobie, A; Wakenhut, F; Whitlock, GA 4-Piperidines and 3-pyrrolidines as dual serotonin and noradrenaline reuptake inhibitors: design, synthesis and structure-activity relationships. Bioorg Med Chem Lett19:2829-34 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 2D6 |
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| Name: | Cytochrome P450 2D6 |
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| Synonyms: | CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1 |
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| Type: | Protein |
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| Mol. Mass.: | 55774.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P10635 |
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| Residue: | 497 |
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| Sequence: | MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
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| BDBM50294270 |
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| n/a |
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| Name | BDBM50294270 |
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| Synonyms: | 3-((2,3-dichlorophenoxy)(piperidin-4-yl)methyl)pyridine | CHEMBL559456 | rac-3-((2,3-dichlorophenoxy)(piperidin-4-yl)methyl)pyridine |
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| Type | Small organic molecule |
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| Emp. Form. | C17H18Cl2N2O |
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| Mol. Mass. | 337.244 |
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| SMILES | Clc1cccc(OC(C2CCNCC2)c2cccnc2)c1Cl |
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| Structure | 
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