| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cytochrome P450 2D6 |
|---|
| Ligand | BDBM50294257 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_575311 (CHEMBL1023618) |
|---|
| IC50 | 5300±n/a nM |
|---|
| Citation |  Fish, PV; Andrews, MD; Jonathan Fray, M; Stobie, A; Wakenhut, F; Whitlock, GA 4-Piperidines and 3-pyrrolidines as dual serotonin and noradrenaline reuptake inhibitors: design, synthesis and structure-activity relationships. Bioorg Med Chem Lett19:2829-34 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cytochrome P450 2D6 |
|---|
| Name: | Cytochrome P450 2D6 |
|---|
| Synonyms: | CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 55774.82 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P10635 |
|---|
| Residue: | 497 |
|---|
| Sequence: | MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
|
|
|
|---|
| BDBM50294257 |
|---|
| n/a |
|---|
| Name | BDBM50294257 |
|---|
| Synonyms: | 2-((2,3-dichlorophenoxy)((S)-pyrrolidin-3-yl)methyl)pyridine | CHEMBL563495 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H16Cl2N2O |
|---|
| Mol. Mass. | 323.217 |
|---|
| SMILES | Clc1cccc(OC([C@H]2CCNC2)c2ccccn2)c1Cl |r| |
|---|
| Structure | 
|
|---|
Search and Browse
