Reaction Details | |||
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Target | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Ligand | BDBM50294770 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_576303 (CHEMBL1030305) | ||
IC50 | 16±n/a nM | ||
Citation | Roche, D; Carniato, D; Leriche, C; Lepifre, F; Christmann-Franck, S; Graedler, U; Charon, C; Bozec, S; Doare, L; Schmidlin, F; Lecomte, M; Valeur, E Discovery and structure-activity relationships of pentanedioic acid diamides as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type I. Bioorg Med Chem Lett19:2674-8 (2009) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
11-beta-hydroxysteroid dehydrogenase 1 | |||
Name: | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 32409.16 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P28845 | ||
Residue: | 292 | ||
Sequence: |
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BDBM50294770 | |||
n/a | |||
Name | BDBM50294770 | ||
Synonyms: | CHEMBL560250 | N-Adamantan-2-yl-2-(1-{[(pyridin-2-ylmethyl)-carbamoyl]-methyl}-cyclopentyl)-acetamide | ||
Type | Small organic molecule | ||
Emp. Form. | C25H35N3O2 | ||
Mol. Mass. | 409.5643 | ||
SMILES | O=C(CC1(CC(=O)NC2C3CC4CC(C3)CC2C4)CCCC1)NCc1ccccn1 |TLB:14:13:17:10.9.8,14:9:12.13.15:17,THB:8:9:12:15.16.17,8:16:12:10.14.9,7:8:12.13.15:17,(23,-13.1,;23,-11.56,;21.66,-10.79,;20.33,-11.56,;18.99,-10.8,;17.66,-11.57,;17.66,-13.11,;16.32,-10.81,;15.04,-11.66,;15.03,-13.19,;13.64,-13.53,;12.31,-13.05,;11.11,-14.33,;12.61,-13.91,;14.02,-14.47,;12.61,-12.32,;13.65,-11.09,;12.3,-11.56,;19.09,-12.48,;19.58,-13.94,;21.12,-13.93,;21.58,-12.46,;24.33,-10.79,;25.66,-11.55,;27,-10.78,;28.32,-11.55,;29.65,-10.78,;29.65,-9.24,;28.31,-8.47,;26.98,-9.25,)| | ||
Structure |