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Target11-beta-hydroxysteroid dehydrogenase 1
LigandBDBM50294785
Substrate/Competitorn/a
Meas. Tech.ChEMBL_576303 (CHEMBL1030305)
IC50 550±n/a nM
Citation Roche, D; Carniato, D; Leriche, C; Lepifre, F; Christmann-Franck, S; Graedler, U; Charon, C; Bozec, S; Doare, L; Schmidlin, F; Lecomte, M; Valeur, E Discovery and structure-activity relationships of pentanedioic acid diamides as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type I. Bioorg Med Chem Lett19:2674-8 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
11-beta-hydroxysteroid dehydrogenase 1
Name:11-beta-hydroxysteroid dehydrogenase 1
Synonyms:11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:Enzyme
Mol. Mass.:32409.16
Organism:Homo sapiens (Human)
Description:P28845
Residue:292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
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  Blast E-value cutoff:
BDBM50294785
n/a
NameBDBM50294785
Synonyms:3,3-Dimethyl-pentanedioic acid cyclopropylamide(5-hydroxy-adamantan-2-yl)-amide | CHEMBL552519
TypeSmall organic molecule
Emp. Form.C20H32N2O3
Mol. Mass.348.4797
SMILESCC(C)(CC(=O)NC1CC1)CC(=O)N[C@H]1C2CC3CC1C[C@@](O)(C3)C2 |r,wU:14.14,21.23,TLB:18:17:24:20.19.14,18:19:23.17.16:24,14:15:23:20.18.19,THB:14:19:23:16.15.24,13:14:23.17.16:24,(-.41,-18.77,;.69,-17.68,;1.77,-18.77,;2.03,-16.92,;3.36,-17.69,;3.35,-19.23,;4.69,-16.93,;6.02,-17.71,;6.79,-19.04,;7.57,-17.71,;-.64,-16.91,;-1.98,-17.67,;-1.99,-19.21,;-3.31,-16.89,;-4.58,-17.77,;-4.56,-19.27,;-6.09,-19.78,;-7.57,-19.19,;-7.56,-17.68,;-6,-17.21,;-6.84,-18.38,;-6.88,-19.79,;-6.89,-21.33,;-8.51,-20.43,;-5.5,-20.35,)|
Structure
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