| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Stearoyl-CoA desaturase |
|---|
| Ligand | BDBM50296305 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_577394 (CHEMBL1056246) |
|---|
| IC50 | 0.6±n/a nM |
|---|
| Citation |  Uto, Y; Ogata, T; Kiyotsuka, Y; Miyazawa, Y; Ueno, Y; Kurata, H; Deguchi, T; Yamada, M; Watanabe, N; Takagi, T; Wakimoto, S; Okuyama, R; Konishi, M; Kurikawa, N; Kono, K; Osumi, J Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part II: Identification of 4-ethylamino-3-(2-hydroxyethoxy)-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide and its biological evaluation. Bioorg Med Chem Lett19:4159-66 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Stearoyl-CoA desaturase |
|---|
| Name: | Stearoyl-CoA desaturase |
|---|
| Synonyms: | Acyl-CoA desaturase | FADS5 | SCD | SCD1 | SCDOS | SCD_HUMAN | Stearoyl-CoA (SCD1) | Stearoyl-CoA desaturase 1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 41537.27 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O00767 |
|---|
| Residue: | 359 |
|---|
| Sequence: | MPAHLLQDDISSSYTTTTTITAPPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYK
DKEGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGAH
RLWSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFS
HVGWLLVRKHPAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGE
TFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNY
HHSFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAILARIKRTGDGNYKSG
|
|
|
|---|
| BDBM50296305 |
|---|
| n/a |
|---|
| Name | BDBM50296305 |
|---|
| Synonyms: | 3-(2-hydroxyethoxy)-4-(2-methoxyethoxy)-N-(5-(3-(trifluoromethyl)benzyl)thiazol-2-yl)benzamide | CHEMBL549625 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H23F3N2O5S |
|---|
| Mol. Mass. | 496.499 |
|---|
| SMILES | COCCOc1ccc(cc1OCCO)C(=O)Nc1ncc(Cc2cccc(c2)C(F)(F)F)s1 |
|---|
| Structure | 
|
|---|
Search and Browse
