| Reaction Details |
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 | Report a problem with these data |
| Target | Melanin-concentrating hormone receptor 1 |
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| Ligand | BDBM50297046 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_580990 (CHEMBL1057278) |
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| IC50 | >1000±n/a nM |
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| Citation |  Kishino, H; Moriya, M; Sakuraba, S; Sakamoto, T; Takahashi, H; Suzuki, T; Moriya, R; Ito, M; Iwaasa, H; Takenaga, N; Ishihara, A; Kanatani, A; Sato, N; Fukami, T Discovery of imidazo[1,2-a]pyridines as potent MCH1R antagonists. Bioorg Med Chem Lett19:4589-93 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanin-concentrating hormone receptor 1 |
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| Name: | Melanin-concentrating hormone receptor 1 |
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| Synonyms: | G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 45976.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays. |
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| Residue: | 422 |
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| Sequence: | MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARL
WEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTIC
LLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHF
GETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALS
FISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRI
LQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVY
LYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESK
GT
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| BDBM50297046 |
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| n/a |
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| Name | BDBM50297046 |
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| Synonyms: | CHEMBL562537 | ethyl 6-(4'-(trifluoromethyl)biphenyl-4-ylcarboxamido)imidazo[1,2-a]pyridine-2-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C24H18F3N3O3 |
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| Mol. Mass. | 453.4132 |
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| SMILES | CCOC(=O)c1cn2cc(NC(=O)c3ccc(cc3)-c3ccc(cc3)C(F)(F)F)ccc2n1 |
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| Structure | 
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