Reaction Details |
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Target | Muscarinic acetylcholine receptor M3 |
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Ligand | BDBM50297129 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_581789 (CHEMBL1061576) |
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IC50 | 1939±n/a nM |
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Citation | Wan, Z; Laine, DI; Yan, H; Zhu, C; Widdowson, KL; Buckley, PT; Burman, M; Foley, JJ; Sarau, HM; Schmidt, DB; Webb, EF; Belmonte, KE; Palovich, M Discovery of (3-endo)-3-(2-cyano-2,2-diphenylethyl)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane bromide as an efficacious inhaled muscarinic acetylcholine receptor antagonist for the treatment of COPD. Bioorg Med Chem Lett19:4560-2 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Muscarinic acetylcholine receptor M3 |
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Name: | Muscarinic acetylcholine receptor M3 |
Synonyms: | ACM3_HUMAN | CHRM3 | Cholinergic, muscarinic M3 | Muscarinic Receptors M3 | Muscarinic receptor M3 | RecName: Full=Muscarinic acetylcholine receptor M3 |
Type: | Enzyme |
Mol. Mass.: | 66151.03 |
Organism: | Homo sapiens (Human) |
Description: | P20309 |
Residue: | 590 |
Sequence: | MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPL
GGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVI
SMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKR
TTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAF
YMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSM
KRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSE
TRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSF
PKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKR
MSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVN
PVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
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BDBM50297129 |
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n/a |
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Name | BDBM50297129 |
Synonyms: | CHEMBL552481 | endo-1-ethyl-3-(3-(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)-2,2-diphenylpropyl)urea |
Type | Small organic molecule |
Emp. Form. | C26H35N3O |
Mol. Mass. | 405.5756 |
SMILES | CCNC(=O)NCC(CC1C[C@H]2CC[C@H](C1)N2C)(c1ccccc1)c1ccccc1 |r,TLB:17:16:9.10.15:12.13,8:9:16:12.13| |
Structure |
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