| Reaction Details |
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 | Report a problem with these data |
| Target | Bifunctional epoxide hydrolase 2 |
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| Ligand | BDBM50297414 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_582789 (CHEMBL1058193) |
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| EC50 | 0.3±n/a nM |
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| Citation |  Eldrup, AB; Soleymanzadeh, F; Taylor, SJ; Muegge, I; Farrow, NA; Joseph, D; McKellop, K; Man, CC; Kukulka, A; De Lombaert, S Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase. J Med Chem52:5880-95 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bifunctional epoxide hydrolase 2 |
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| Name: | Bifunctional epoxide hydrolase 2 |
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| Synonyms: | Cytosolic epoxide hydrolase 2 | EBifunctional epoxide hydrolase 2 | EPHX2 | Epoxide hydratase | HYES_HUMAN | Lipid-phosphate phosphatase | Soluble epoxide hydrolase (sEH) | epoxide hydrolase 2, cytoplasmic |
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| Type: | Enzyme |
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| Mol. Mass.: | 62613.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P34913 |
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| Residue: | 555 |
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| Sequence: | MTLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITL
SQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTA
ILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEV
VFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHG
YVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESS
APPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNT
PFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMH
KVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSL
GRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIK
WLDSDARNPPVVSKM
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| BDBM50297414 |
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| n/a |
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| Name | BDBM50297414 |
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| Synonyms: | CHEMBL556234 | N-[3-(4-Fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-6-(2,2,2-trifluoro-ethoxy)-nicotinamide |
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| Type | Small organic molecule |
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| Emp. Form. | C24H22F4N2O4S |
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| Mol. Mass. | 510.501 |
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| SMILES | CS(=O)(=O)c1ccc(cc1)C(CCNC(=O)c1ccc(OCC(F)(F)F)nc1)c1ccc(F)cc1 |
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| Structure | 
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