| Reaction Details |
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 | Report a problem with these data |
| Target | Renin |
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| Ligand | BDBM50298194 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_585345 (CHEMBL1054384) |
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| IC50 | 2±n/a nM |
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| Citation |  Yamaguchi, Y; Menear, K; Cohen, NC; Mah, R; Cumin, F; Schnell, C; Wood, JM; Maibaum, J The P1N-isopropyl motif bearing hydroxyethylene dipeptide isostere analogues of aliskiren are in vitro potent inhibitors of the human aspartyl protease renin. Bioorg Med Chem Lett19:4863-7 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Renin |
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| Name: | Renin |
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| Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 45058.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 406 |
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| Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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| BDBM50298194 |
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| n/a |
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| Name | BDBM50298194 |
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| Synonyms: | CHEMBL561141 | methyl 5-(((2S,3S,5R)-2-amino-6-(butylamino)-3-hydroxy-5-methyl-6-oxohexyl)(isopropyl)carbamoyl)-2-methoxybenzylcarbamate |
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| Type | Small organic molecule |
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| Emp. Form. | C25H42N4O6 |
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| Mol. Mass. | 494.6242 |
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| SMILES | CCCCNC(=O)[C@H](C)C[C@H](O)[C@@H](N)CN(C(C)C)C(=O)c1ccc(OC)c(CNC(=O)OC)c1 |r| |
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| Structure | 
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