| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM26521 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_588096 (CHEMBL1044822) |
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| IC50 | 57±n/a nM |
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| Citation |  Paulsen, JL; Liu, J; Bolstad, DB; Smith, AE; Priestley, ND; Wright, DL; Anderson, AC In vitro biological activity and structural analysis of 2,4-diamino-5-(2'-arylpropargyl)pyrimidine inhibitors of Candida albicans. Bioorg Med Chem17:4866-72 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 21453.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human DHFR. |
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| Residue: | 187 |
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| Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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| BDBM26521 |
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| n/a |
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| Name | BDBM26521 |
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| Synonyms: | 6-ethyl-5-[3-(3,4,5-trimethoxyphenyl)prop-1-yn-1-yl]pyrimidine-2,4-diamine | Propargyl inhibitor, 20 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H22N4O3 |
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| Mol. Mass. | 342.3923 |
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| SMILES | CCc1nc(N)nc(N)c1C#CCc1cc(OC)c(OC)c(OC)c1 |
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| Structure | 
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