| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Alpha-1B adrenergic receptor |
|---|
| Ligand | BDBM50299208 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_592536 (CHEMBL1046743) |
|---|
| IC50 | 102±n/a nM |
|---|
| Citation |  Biancalani, C; Giovannoni, MP; Pieretti, S; Cesari, N; Graziano, A; Vergelli, C; Cilibrizzi, A; Di Gianuario, A; Colucci, M; Mangano, G; Garrone, B; Polenzani, L; Dal Piaz, V Further studies on arylpiperazinyl alkyl pyridazinones: discovery of an exceptionally potent, orally active, antinociceptive agent in thermally induced pain. J Med Chem52:7397-409 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Alpha-1B adrenergic receptor |
|---|
| Name: | Alpha-1B adrenergic receptor |
|---|
| Synonyms: | ADA1B_RAT | Adra1b | Alpha 1B-adrenoceptor | Alpha 1B-adrenoreceptor | Alpha adrenergic receptor 1A and 1B | Alpha-1 Adrenergic Receptor | Alpha-1Adrenoceptor | Alpha-1B adrenergic receptor | Alpha-1B adrenoreceptor | adrenergic Alpha1B |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 56606.71 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | Receptor binding assays were performed using rat cortical membranes. |
|---|
| Residue: | 515 |
|---|
| Sequence: | MNPDLDTGHNTSAPAHWGELKDDNFTGPNQTSSNSTLPQLDVTRAISVGLVLGAFILFAI
VGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTVLPFSATLEVLGYWVLGRIFCDI
WAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGP
LLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAG
VMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVV
GMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFM
RILGCQCRGGRRRRRRRRLGACAYTYRPWTRGGSLERSQSRKDSLDDSGSCMSGTQRTLP
SASPSPGYLGRGTQPPVELCAFPEWKPGALLSLPEPPGRRGRLDSGPLFTFKLLGDPESP
GTEGDTSNGGCDTTTDLANGQPGFKSNMPLAPGHF
|
|
|
|---|
| BDBM50299208 |
|---|
| n/a |
|---|
| Name | BDBM50299208 |
|---|
| Synonyms: | 4-amino-6-methyl-2-(3-(4-p-tolylpiperazin-1-yl)propyl)-5-vinylpyridazin-3(2H)-one | CHEMBL584606 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H29N5O |
|---|
| Mol. Mass. | 367.4879 |
|---|
| SMILES | Cc1ccc(cc1)N1CCN(CCCn2nc(C)c(C=C)c(N)c2=O)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
