| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase pim-3 |
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| Ligand | BDBM50299245 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_589580 (CHEMBL1051396) |
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| IC50 | 40±n/a nM |
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| Citation |  Akué-Gédu, R; Rossignol, E; Azzaro, S; Knapp, S; Filippakopoulos, P; Bullock, AN; Bain, J; Cohen, P; Prudhomme, M; Anizon, F; Moreau, P Synthesis, kinase inhibitory potencies, and in vitro antiproliferative evaluation of new Pim kinase inhibitors. J Med Chem52:6369-81 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase pim-3 |
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| Name: | Serine/threonine-protein kinase pim-3 |
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| Synonyms: | PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3) |
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| Type: | Protein |
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| Mol. Mass.: | 35888.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q86V86 |
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| Residue: | 326 |
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| Sequence: | MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRI
ADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFL
LVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDL
RSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVC
GDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGV
PESCDLRLCTLDPDDVASTTSSSESL
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| BDBM50299245 |
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| n/a |
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| Name | BDBM50299245 |
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| Synonyms: | 7-Bromo-1,10-dihydropyrrolo[2,3-a]carbazole-3-carbaldehyde | CHEMBL584195 | US8481586, 16 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H9BrN2O |
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| Mol. Mass. | 313.149 |
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| SMILES | Brc1ccc2[nH]c3c(ccc4c(C=O)c[nH]c34)c2c1 |
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| Structure | 
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