| Reaction Details |
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 | Report a problem with these data |
| Target | Neuromedin-K receptor |
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| Ligand | BDBM50299468 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_590802 (CHEMBL1037640) |
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| Ki | 1.6±n/a nM |
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| Citation |  Malherbe, P; Kratzeisen, C; Marcuz, A; Zenner, MT; Nettekoven, MH; Ratni, H; Wettstein, JG; Bissantz, C Identification of a critical residue in the transmembrane domain 2 of tachykinin neurokinin 3 receptor affecting the dissociation kinetics and antagonism mode of osanetant (SR 142801) and piperidine-based structures. J Med Chem52:7103-12 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuromedin-K receptor |
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| Name: | Neuromedin-K receptor |
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| Synonyms: | NK3R_CAVPO | Neurokinin 3 receptor | Neurokinin NK3 | Neuromedin-K receptor | TACR3 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 49456.44 |
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| Organism: | GUINEA PIG |
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| Description: | Neurokinin NK3 TACR3 GUINEA PIG::P30098 |
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| Residue: | 440 |
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| Sequence: | MASPAGNLSAWPGWGWPPPAALRNLTSSPAPTASPSPAPSWTPSPRPGPAHPFLQPPWAV
ALWSLAYGAVVAVAVLGNLVVIWIVLAHKRMRTVTNSFLVNLAFADAAMAALNALVNFIY
ALHGEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATRIVIG
SIWILAFLLAFPQCLYSKIKVMPGRTLCYVQWPEGSRQHFTYHMIVIVLVYCFPLLIMGI
TYTIVGITLWGGEIPGDTCDKYQEQLKAKRKVVKMMIIVVVTFAICWLPYHIYFILTAIY
QQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIHVSSYDEL
ELKATRLHPMRQSSLYTVTRMESMSVVFDSNDGDSARSSHQKRGTTRDVGSNVCSRRNSK
STSTTASFVSSSHMSVEEGS
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| BDBM50299468 |
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| n/a |
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| Name | BDBM50299468 |
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| Synonyms: | 2-(3,4-dichlorophenyl)-N-(4-fluoro-3-trifluoromethylbenzyl)-2,N-dimethyl-4-[4-(2-oxo-pyrrolidin-1-yl)-piperidin-1-yl]-butyramide | CHEMBL565894 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H33Cl2F4N3O2 |
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| Mol. Mass. | 602.491 |
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| SMILES | CN(Cc1ccc(F)c(c1)C(F)(F)F)C(=O)C(C)(CCN1CCC(CC1)N1CCCC1=O)c1ccc(Cl)c(Cl)c1 |
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| Structure | 
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