| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neuromedin-K receptor |
|---|
| Ligand | BDBM50291261 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_590803 (CHEMBL1037641) |
|---|
| Ki | 0.8±n/a nM |
|---|
| Citation |  Malherbe, P; Kratzeisen, C; Marcuz, A; Zenner, MT; Nettekoven, MH; Ratni, H; Wettstein, JG; Bissantz, C Identification of a critical residue in the transmembrane domain 2 of tachykinin neurokinin 3 receptor affecting the dissociation kinetics and antagonism mode of osanetant (SR 142801) and piperidine-based structures. J Med Chem52:7103-12 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Neuromedin-K receptor |
|---|
| Name: | Neuromedin-K receptor |
|---|
| Synonyms: | NK3R_CAVPO | Neurokinin 3 receptor | Neurokinin NK3 | Neuromedin-K receptor | TACR3 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 49456.44 |
|---|
| Organism: | GUINEA PIG |
|---|
| Description: | Neurokinin NK3 TACR3 GUINEA PIG::P30098 |
|---|
| Residue: | 440 |
|---|
| Sequence: | MASPAGNLSAWPGWGWPPPAALRNLTSSPAPTASPSPAPSWTPSPRPGPAHPFLQPPWAV
ALWSLAYGAVVAVAVLGNLVVIWIVLAHKRMRTVTNSFLVNLAFADAAMAALNALVNFIY
ALHGEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATRIVIG
SIWILAFLLAFPQCLYSKIKVMPGRTLCYVQWPEGSRQHFTYHMIVIVLVYCFPLLIMGI
TYTIVGITLWGGEIPGDTCDKYQEQLKAKRKVVKMMIIVVVTFAICWLPYHIYFILTAIY
QQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIHVSSYDEL
ELKATRLHPMRQSSLYTVTRMESMSVVFDSNDGDSARSSHQKRGTTRDVGSNVCSRRNSK
STSTTASFVSSSHMSVEEGS
|
|
|
|---|
| BDBM50291261 |
|---|
| n/a |
|---|
| Name | BDBM50291261 |
|---|
| Synonyms: | (S)-(+)-N-((3-[1-Benzoyl-3-(3,4-dichlorophenyl)piperidin-3-yl]prop-1-yl)-4-phenylpiperidin-4-yl)-N-methylacetamine | CHEMBL2311148 | CHEMBL346178 | N-(1-{3-[(R)-1-Benzoyl-3-(3,4-dichloro-phenyl)-piperidin-3-yl]-propyl}-4-phenyl-piperidin-4-yl)-N-methyl-acetamide | OSANETANT | SB-236984 | SR-14280 | SR-142801 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C35H41Cl2N3O2 |
|---|
| Mol. Mass. | 606.625 |
|---|
| SMILES | CN(C(C)=O)C1(CCN(CCC[C@@]2(CCCN(C2)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1)c1ccccc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
