| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Glutaminyl-peptide cyclotransferase |
|---|
| Ligand | BDBM50299858 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_589681 (CHEMBL1057686) |
|---|
| Ki | 2.6±n/a nM |
|---|
| Citation |  Buchholz, M; Hamann, A; Aust, S; Brandt, W; Böhme, L; Hoffmann, T; Schilling, S; Demuth, HU; Heiser, U Inhibitors for human glutaminyl cyclase by structure based design and bioisosteric replacement. J Med Chem52:7069-80 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Glutaminyl-peptide cyclotransferase |
|---|
| Name: | Glutaminyl-peptide cyclotransferase |
|---|
| Synonyms: | Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 40877.05 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q16769 |
|---|
| Residue: | 361 |
|---|
| Sequence: | MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGT
SISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSF
SNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLS
LKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHG
MDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYG
GVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLH
L
|
|
|
|---|
| BDBM50299858 |
|---|
| n/a |
|---|
| Name | BDBM50299858 |
|---|
| Synonyms: | 1-(3,4-Dimethoxyphenyl)-N-(3-(5-methyl-1H-imidazol-1-yl)propyl)cyclopropanecarbothioamide | CHEMBL583368 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H25N3O2S |
|---|
| Mol. Mass. | 359.486 |
|---|
| SMILES | COc1ccc(cc1OC)C1(CC1)C(=S)NCCCn1cncc1C |
|---|
| Structure | 
|
|---|
Search and Browse
