| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 8 |
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| Ligand | BDBM50299972 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_593050 (CHEMBL1039566) |
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| Ki | 6.59E3±n/a nM |
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| Citation |  He, B; Velaparthi, S; Pieffet, G; Pennington, C; Mahesh, A; Holzle, DL; Brunsteiner, M; van Breemen, R; Blond, SY; Petukhov, PA Binding ensemble profiling with photoaffinity labeling (BEProFL) approach: mapping the binding poses of HDAC8 inhibitors. J Med Chem52:7003-13 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 8 |
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| Name: | Histone deacetylase 8 |
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| Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41749.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BY41 |
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| Residue: | 377 |
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| Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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| BDBM50299972 |
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| n/a |
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| Name | BDBM50299972 |
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| Synonyms: | CHEMBL585164 | Octanedioic Acid [4-(3-Azido-5-azidomethylbenzyloxy)phenyl]-amide Hydroxyamide |
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| Type | Small organic molecule |
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| Emp. Form. | C22H26N8O4 |
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| Mol. Mass. | 466.493 |
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| SMILES | ONC(=O)CCCCCCC(=O)Nc1ccc(OCc2cc(CN=[N+]=[N-])cc(c2)N=[N+]=[N-])cc1 |
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| Structure | 
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