| Reaction Details |
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 | Report a problem with these data |
| Target | Glutathione reductase, mitochondrial |
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| Ligand | BDBM50300754 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_589949 (CHEMBL1050857) |
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| IC50 | >50000±n/a nM |
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| Citation |  Rai, G; Sayed, AA; Lea, WA; Luecke, HF; Chakrapani, H; Prast-Nielsen, S; Jadhav, A; Leister, W; Shen, M; Inglese, J; Austin, CP; Keefer, L; Arnér, ES; Simeonov, A; Maloney, DJ; Williams, DL; Thomas, CJ Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis. J Med Chem52:6474-83 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutathione reductase, mitochondrial |
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| Name: | Glutathione reductase, mitochondrial |
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| Synonyms: | GLUR | GRD1 | GSHR_HUMAN | GSR | Glutathione reductase | Glutathione reductase (GR) |
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| Type: | Enzyme |
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| Mol. Mass.: | 56271.52 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00390 |
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| Residue: | 522 |
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| Sequence: | MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAG
AVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHS
EFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDP
KPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAG
YIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKK
TLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVD
EFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPP
IGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQ
GLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR
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| BDBM50300754 |
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| n/a |
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| Name | BDBM50300754 |
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| Synonyms: | 2-Oxy-4-phenyl-furazan-3-carboxylic acid amide | 3-carbamoyl-4-phenyl-1,2,5-oxadiazole 2-oxide | CHEMBL500868 |
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| Type | Small organic molecule |
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| Emp. Form. | C9H7N3O3 |
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| Mol. Mass. | 205.1702 |
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| SMILES | NC(=O)c1c(no[n+]1[O-])-c1ccccc1 |
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| Structure | 
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