| Reaction Details |
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 | Report a problem with these data |
| Target | Neuronal acetylcholine receptor subunit alpha-7 |
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| Ligand | BDBM50300810 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_598737 (CHEMBL1039307) |
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| EC50 | 6030±n/a nM |
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| Citation |  Haydar, SN; Ghiron, C; Bettinetti, L; Bothmann, H; Comery, TA; Dunlop, J; La Rosa, S; Micco, I; Pollastrini, M; Quinn, J; Roncarati, R; Scali, C; Valacchi, M; Varrone, M; Zanaletti, R SAR and biological evaluation of SEN12333/WAY-317538: Novel alpha 7 nicotinic acetylcholine receptor agonist. Bioorg Med Chem17:5247-58 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuronal acetylcholine receptor subunit alpha-7 |
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| Name: | Neuronal acetylcholine receptor subunit alpha-7 |
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| Synonyms: | ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR) |
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| Type: | Enzyme |
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| Mol. Mass.: | 56502.44 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | Q05941 |
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| Residue: | 502 |
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| Sequence: | MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLL
QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADE
RFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDL
QMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIP
CVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAST
MIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHK
PRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHL
MHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTI
ICTIGILMSAPNFVEAVSKDFA
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| BDBM50300810 |
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| n/a |
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| Name | BDBM50300810 |
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| Synonyms: | 2'-Fluoro-biphenyl-4-carboxylic acid{4-[4-(2,4-dimethoxy-phenyl)-piperazin-1-yl]-butyl}-amide | CHEMBL578997 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H34FN3O3 |
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| Mol. Mass. | 491.597 |
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| SMILES | COc1ccc(N2CCN(CCCCNC(=O)c3ccc(cc3)-c3ccccc3F)CC2)c(OC)c1 |
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| Structure | 
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