Compile Data Set for Download or QSAR

Found 30 hits with Last Name = 'pollastrini' and Initial = 'm'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50300802 (5-Morpholin-4-ylpentanoic acid(4-pyridin-3-ylpheny...) Show SMILES O=C(CCCCN1CCOCC1)Nc1ccc(cc1)-c1cccnc1 Show InChI InChI=1S/C20H25N3O2/c24-20(5-1-2-11-23-12-14-25-15-13-23)22-19-8-6-17(7-9-19)18-4-3-10-21-16-18/h3-4,6-10,16H,1-2,5,11-15H2,(H,22,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	260	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [3H]epibatidine from rat rat alpha7 nAChR expressed in rat GH4C1 cells				Bioorg Med Chem 17: 5247-58 (2009) Article DOI: 10.1016/j.bmc.2009.05.040 BindingDB Entry DOI: 10.7270/Q29K4B8H
					More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Homo sapiens (Human))	BDBM50436849 (CHEMBL2403768 | US8999980, I-9) Show SMILES C[C@]1(CCOC(N)=N1)c1cc(NC(=O)c2ncc(Cl)cc2Cl)ccc1F |r,c:6| Show InChI InChI=1S/C17H15Cl2FN4O2/c1-17(4-5-26-16(21)24-17)11-7-10(2-3-13(11)20)23-15(25)14-12(19)6-9(18)8-22-14/h2-3,6-8H,4-5H2,1H3,(H2,21,24)(H,23,25)/t17-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	900	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Inhibition of CYP2D6 (unknown origin)				Bioorg Med Chem Lett 23: 4239-43 (2013) Article DOI: 10.1016/j.bmcl.2013.05.003 BindingDB Entry DOI: 10.7270/Q2KS6SXQ
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50300799 (5-[Methyl-(2-pyridin-2-ylethyl)amino]pentanoic aci...) Show SMILES CN(CCCCC(=O)Nc1ccc(cc1)-c1cccnc1)CCc1ccccn1 Show InChI InChI=1S/C24H28N4O/c1-28(18-14-22-8-2-4-16-26-22)17-5-3-9-24(29)27-23-12-10-20(11-13-23)21-7-6-15-25-19-21/h2,4,6-8,10-13,15-16,19H,3,5,9,14,17-18H2,1H3,(H,27,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	3.27E+3	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonist activity at rat alpha7 nAChR expressed in rat GH4C1 cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 17: 5247-58 (2009) Article DOI: 10.1016/j.bmc.2009.05.040 BindingDB Entry DOI: 10.7270/Q29K4B8H
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50300800 (5-(4-Acetylpiperazin-1-yl)pentanoic acid(4-pyridin...) Show SMILES CC(=O)N1CCN(CCCCC(=O)Nc2ccc(cc2)-c2cccnc2)CC1 Show InChI InChI=1S/C22H28N4O2/c1-18(27)26-15-13-25(14-16-26)12-3-2-6-22(28)24-21-9-7-19(8-10-21)20-5-4-11-23-17-20/h4-5,7-11,17H,2-3,6,12-16H2,1H3,(H,24,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	2.78E+3	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonist activity at rat alpha7 nAChR expressed in rat GH4C1 cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 17: 5247-58 (2009) Article DOI: 10.1016/j.bmc.2009.05.040 BindingDB Entry DOI: 10.7270/Q29K4B8H
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50300801 (5-[4-(2-Methoxyphenyl)piperazin-1-yl]pentanoic aci...) Show SMILES COc1ccccc1N1CCN(CCCCC(=O)Nc2ccc(cc2)-c2cccnc2)CC1 Show InChI InChI=1S/C27H32N4O2/c1-33-26-9-3-2-8-25(26)31-19-17-30(18-20-31)16-5-4-10-27(32)29-24-13-11-22(12-14-24)23-7-6-15-28-21-23/h2-3,6-9,11-15,21H,4-5,10,16-20H2,1H3,(H,29,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	2.47E+3	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonist activity at rat alpha7 nAChR expressed in rat GH4C1 cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 17: 5247-58 (2009) Article DOI: 10.1016/j.bmc.2009.05.040 BindingDB Entry DOI: 10.7270/Q29K4B8H
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50300802 (5-Morpholin-4-ylpentanoic acid(4-pyridin-3-ylpheny...) Show SMILES O=C(CCCCN1CCOCC1)Nc1ccc(cc1)-c1cccnc1 Show InChI InChI=1S/C20H25N3O2/c24-20(5-1-2-11-23-12-14-25-15-13-23)22-19-8-6-17(7-9-19)18-4-3-10-21-16-18/h3-4,6-10,16H,1-2,5,11-15H2,(H,22,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.65E+3	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonist activity at rat alpha7 nAChR expressed in rat GH4C1 cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 17: 5247-58 (2009) Article DOI: 10.1016/j.bmc.2009.05.040 BindingDB Entry DOI: 10.7270/Q29K4B8H
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50300803 (5-(piperidin-1-yl)-N-(4-(pyridin-3-yl)phenyl)penta...) Show SMILES O=C(CCCCN1CCCCC1)Nc1ccc(cc1)-c1cccnc1 Show InChI InChI=1S/C21H27N3O/c25-21(8-2-5-16-24-14-3-1-4-15-24)23-20-11-9-18(10-12-20)19-7-6-13-22-17-19/h6-7,9-13,17H,1-5,8,14-16H2,(H,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	530	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonist activity at rat alpha7 nAChR expressed in rat GH4C1 cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 17: 5247-58 (2009) Article DOI: 10.1016/j.bmc.2009.05.040 BindingDB Entry DOI: 10.7270/Q29K4B8H
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50300804 (4-Nitro-N-{4-[4-(2,4-dimethoxyphenyl)piperazin-1-y...) Show SMILES COc1ccc(N2CCN(CCCCNC(=O)c3ccc(cc3)[N+]([O-])=O)CC2)c(OC)c1 Show InChI InChI=1S/C23H30N4O5/c1-31-20-9-10-21(22(17-20)32-2)26-15-13-25(14-16-26)12-4-3-11-24-23(28)18-5-7-19(8-6-18)27(29)30/h5-10,17H,3-4,11-16H2,1-2H3,(H,24,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonist activity at rat alpha7 nAChR expressed in rat GH4C1 cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 17: 5247-58 (2009) Article DOI: 10.1016/j.bmc.2009.05.040 BindingDB Entry DOI: 10.7270/Q29K4B8H
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50300805 (4-Bromo-N-{4-[4-(2,4-dimethoxyphenyl)piperazin-1-y...) Show SMILES COc1ccc(N2CCN(CCCCNC(=O)c3ccc(Br)cc3)CC2)c(OC)c1 Show InChI InChI=1S/C23H30BrN3O3/c1-29-20-9-10-21(22(17-20)30-2)27-15-13-26(14-16-27)12-4-3-11-25-23(28)18-5-7-19(24)8-6-18/h5-10,17H,3-4,11-16H2,1-2H3,(H,25,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonist activity at rat alpha7 nAChR expressed in rat GH4C1 cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 17: 5247-58 (2009) Article DOI: 10.1016/j.bmc.2009.05.040 BindingDB Entry DOI: 10.7270/Q29K4B8H
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50300806 (Biphenyl-4-carboxylic acid{4-[4-(2,4-dimethoxyphen...) Show SMILES COc1ccc(N2CCN(CCCCNC(=O)c3ccc(cc3)-c3ccccc3)CC2)c(OC)c1 Show InChI InChI=1S/C29H35N3O3/c1-34-26-14-15-27(28(22-26)35-2)32-20-18-31(19-21-32)17-7-6-16-30-29(33)25-12-10-24(11-13-25)23-8-4-3-5-9-23/h3-5,8-15,22H,6-7,16-21H2,1-2H3,(H,30,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonist activity at rat alpha7 nAChR expressed in rat GH4C1 cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 17: 5247-58 (2009) Article DOI: 10.1016/j.bmc.2009.05.040 BindingDB Entry DOI: 10.7270/Q29K4B8H
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50300807 (2'-Methoxybiphenyl-4-carboxylic acid{4-[4-(2,4-dim...) Show SMILES COc1ccc(N2CCN(CCCCNC(=O)c3ccc(cc3)-c3ccccc3OC)CC2)c(OC)c1 Show InChI InChI=1S/C30H37N3O4/c1-35-25-14-15-27(29(22-25)37-3)33-20-18-32(19-21-33)17-7-6-16-31-30(34)24-12-10-23(11-13-24)26-8-4-5-9-28(26)36-2/h4-5,8-15,22H,6-7,16-21H2,1-3H3,(H,31,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.91E+3	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonist activity at rat alpha7 nAChR expressed in rat GH4C1 cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 17: 5247-58 (2009) Article DOI: 10.1016/j.bmc.2009.05.040 BindingDB Entry DOI: 10.7270/Q29K4B8H
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50300808 (2'-Methylbiphenyl-4-carboxylic acid{4-[4-(2,4-dime...) Show SMILES COc1ccc(N2CCN(CCCCNC(=O)c3ccc(cc3)-c3ccccc3C)CC2)c(OC)c1 Show InChI InChI=1S/C30H37N3O3/c1-23-8-4-5-9-27(23)24-10-12-25(13-11-24)30(34)31-16-6-7-17-32-18-20-33(21-19-32)28-15-14-26(35-2)22-29(28)36-3/h4-5,8-15,22H,6-7,16-21H2,1-3H3,(H,31,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	5.77E+3	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonist activity at rat alpha7 nAChR expressed in rat GH4C1 cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 17: 5247-58 (2009) Article DOI: 10.1016/j.bmc.2009.05.040 BindingDB Entry DOI: 10.7270/Q29K4B8H
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50300809 (2'-Chlorobiphenyl-4-carboxylic acid{4-[4-(2,4-dime...) Show SMILES COc1ccc(N2CCN(CCCCNC(=O)c3ccc(cc3)-c3ccccc3Cl)CC2)c(OC)c1 Show InChI InChI=1S/C29H34ClN3O3/c1-35-24-13-14-27(28(21-24)36-2)33-19-17-32(18-20-33)16-6-5-15-31-29(34)23-11-9-22(10-12-23)25-7-3-4-8-26(25)30/h3-4,7-14,21H,5-6,15-20H2,1-2H3,(H,31,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	3.11E+3	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonist activity at rat alpha7 nAChR expressed in rat GH4C1 cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 17: 5247-58 (2009) Article DOI: 10.1016/j.bmc.2009.05.040 BindingDB Entry DOI: 10.7270/Q29K4B8H
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50300810 (2'-Fluoro-biphenyl-4-carboxylic acid{4-[4-(2,4-dim...) Show SMILES COc1ccc(N2CCN(CCCCNC(=O)c3ccc(cc3)-c3ccccc3F)CC2)c(OC)c1 Show InChI InChI=1S/C29H34FN3O3/c1-35-24-13-14-27(28(21-24)36-2)33-19-17-32(18-20-33)16-6-5-15-31-29(34)23-11-9-22(10-12-23)25-7-3-4-8-26(25)30/h3-4,7-14,21H,5-6,15-20H2,1-2H3,(H,31,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	6.03E+3	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonist activity at rat alpha7 nAChR expressed in rat GH4C1 cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 17: 5247-58 (2009) Article DOI: 10.1016/j.bmc.2009.05.040 BindingDB Entry DOI: 10.7270/Q29K4B8H
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50300811 (CHEMBL576234 | N-{4-[4-(2,4-dimethoxyphenyl)-piper...) Show SMILES COc1ccc(N2CCN(CCCCNC(=O)c3ccc(cc3)-c3ccccn3)CC2)c(OC)c1 Show InChI InChI=1S/C28H34N4O3/c1-34-24-12-13-26(27(21-24)35-2)32-19-17-31(18-20-32)16-6-5-15-30-28(33)23-10-8-22(9-11-23)25-7-3-4-14-29-25/h3-4,7-14,21H,5-6,15-20H2,1-2H3,(H,30,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.84E+3	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonist activity at rat alpha7 nAChR expressed in rat GH4C1 cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 17: 5247-58 (2009) Article DOI: 10.1016/j.bmc.2009.05.040 BindingDB Entry DOI: 10.7270/Q29K4B8H
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50300802 (5-Morpholin-4-ylpentanoic acid(4-pyridin-3-ylpheny...) Show SMILES O=C(CCCCN1CCOCC1)Nc1ccc(cc1)-c1cccnc1 Show InChI InChI=1S/C20H25N3O2/c24-20(5-1-2-11-23-12-14-25-15-13-23)22-19-8-6-17(7-9-19)18-4-3-10-21-16-18/h3-4,6-10,16H,1-2,5,11-15H2,(H,22,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Activity at rat alpha7 nAChR expressed in rat GH4C1 cells by patch clamp technique				Bioorg Med Chem 17: 5247-58 (2009) Article DOI: 10.1016/j.bmc.2009.05.040 BindingDB Entry DOI: 10.7270/Q29K4B8H
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50300812 (5-Piperidin-1-yl-pentanoic acid(3-bromophenyl)amid...) Show SMILES Brc1cccc(c1)-c1ccc(NC(=O)CCCCN2CCCCC2)cc1 Show InChI InChI=1S/C22H27BrN2O/c23-20-8-6-7-19(17-20)18-10-12-21(13-11-18)24-22(26)9-2-5-16-25-14-3-1-4-15-25/h6-8,10-13,17H,1-5,9,14-16H2,(H,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.07E+3	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonist activity at rat alpha7 nAChR expressed in rat GH4C1 cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 17: 5247-58 (2009) Article DOI: 10.1016/j.bmc.2009.05.040 BindingDB Entry DOI: 10.7270/Q29K4B8H
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50300813 (5-Piperidin-1-ylpentanoic acid(3'-acetylaminobiphe...) Show SMILES CC(=O)Nc1cccc(c1)-c1ccc(NC(=O)CCCCN2CCCCC2)cc1 Show InChI InChI=1S/C24H31N3O2/c1-19(28)25-23-9-7-8-21(18-23)20-11-13-22(14-12-20)26-24(29)10-3-6-17-27-15-4-2-5-16-27/h7-9,11-14,18H,2-6,10,15-17H2,1H3,(H,25,28)(H,26,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	120	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonist activity at rat alpha7 nAChR expressed in rat GH4C1 cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 17: 5247-58 (2009) Article DOI: 10.1016/j.bmc.2009.05.040 BindingDB Entry DOI: 10.7270/Q29K4B8H
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50300814 (5-Piperidin-1-ylpentanoic acid(3'-acetylbiphenyl-4...) Show SMILES CC(=O)c1cccc(c1)-c1ccc(NC(=O)CCCCN2CCCCC2)cc1 Show InChI InChI=1S/C24H30N2O2/c1-19(27)21-8-7-9-22(18-21)20-11-13-23(14-12-20)25-24(28)10-3-6-17-26-15-4-2-5-16-26/h7-9,11-14,18H,2-6,10,15-17H2,1H3,(H,25,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	990	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonist activity at rat alpha7 nAChR expressed in rat GH4C1 cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 17: 5247-58 (2009) Article DOI: 10.1016/j.bmc.2009.05.040 BindingDB Entry DOI: 10.7270/Q29K4B8H
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50300815 (4'-(5-Piperidin-1-yl-pentanoylamino)biphenyl-3-car...) Show SMILES NC(=O)c1cccc(c1)-c1ccc(NC(=O)CCCCN2CCCCC2)cc1 Show InChI InChI=1S/C23H29N3O2/c24-23(28)20-8-6-7-19(17-20)18-10-12-21(13-11-18)25-22(27)9-2-5-16-26-14-3-1-4-15-26/h6-8,10-13,17H,1-5,9,14-16H2,(H2,24,28)(H,25,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	90	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonist activity at rat alpha7 nAChR expressed in rat GH4C1 cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 17: 5247-58 (2009) Article DOI: 10.1016/j.bmc.2009.05.040 BindingDB Entry DOI: 10.7270/Q29K4B8H
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50300816 (5-Piperidin-1-yl-pentanoic acid m-tolylamide | CHE...) Show SMILES Cc1cccc(NC(=O)CCCCN2CCCCC2)c1 Show InChI InChI=1S/C17H26N2O/c1-15-8-7-9-16(14-15)18-17(20)10-3-6-13-19-11-4-2-5-12-19/h7-9,14H,2-6,10-13H2,1H3,(H,18,20)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonist activity at rat alpha7 nAChR expressed in rat GH4C1 cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 17: 5247-58 (2009) Article DOI: 10.1016/j.bmc.2009.05.040 BindingDB Entry DOI: 10.7270/Q29K4B8H
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50300817 (5-Piperidin-1-yl-pentanoic acid benzo[1,3]dioxol-5...) Show SMILES O=C(CCCCN1CCCCC1)Nc1ccc(cc1)-c1ccc2OCOc2c1 Show InChI InChI=1S/C23H28N2O3/c26-23(6-2-5-15-25-13-3-1-4-14-25)24-20-10-7-18(8-11-20)19-9-12-21-22(16-19)28-17-27-21/h7-12,16H,1-6,13-15,17H2,(H,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.09E+4	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonist activity at rat alpha7 nAChR expressed in rat GH4C1 cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 17: 5247-58 (2009) Article DOI: 10.1016/j.bmc.2009.05.040 BindingDB Entry DOI: 10.7270/Q29K4B8H
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50300818 (5-Piperidin-1-yl-pentanoic acid quinolin-6-ylamide...) Show SMILES O=C(CCCCN1CCCCC1)Nc1ccc(cc1)-c1ccc2ncccc2c1 Show InChI InChI=1S/C25H29N3O/c29-25(8-2-5-18-28-16-3-1-4-17-28)27-23-12-9-20(10-13-23)21-11-14-24-22(19-21)7-6-15-26-24/h6-7,9-15,19H,1-5,8,16-18H2,(H,27,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	5.07E+3	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonist activity at rat alpha7 nAChR expressed in rat GH4C1 cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 17: 5247-58 (2009) Article DOI: 10.1016/j.bmc.2009.05.040 BindingDB Entry DOI: 10.7270/Q29K4B8H
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50300819 (5-Piperidin-1-yl-pentanoic acid(4-bromophenyl)amid...) Show SMILES Brc1ccc(cc1)-c1ccc(NC(=O)CCCCN2CCCCC2)cc1 Show InChI InChI=1S/C22H27BrN2O/c23-20-11-7-18(8-12-20)19-9-13-21(14-10-19)24-22(26)6-2-5-17-25-15-3-1-4-16-25/h7-14H,1-6,15-17H2,(H,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.35E+3	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonist activity at rat alpha7 nAChR expressed in rat GH4C1 cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 17: 5247-58 (2009) Article DOI: 10.1016/j.bmc.2009.05.040 BindingDB Entry DOI: 10.7270/Q29K4B8H
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50300793 (5-Piperidin-1-yl-pentanoic acid(2'-isopropoxybiphe...) Show SMILES CC(C)Oc1ccccc1-c1ccc(NC(=O)CCCCN2CCCCC2)cc1 Show InChI InChI=1S/C25H34N2O2/c1-20(2)29-24-11-5-4-10-23(24)21-13-15-22(16-14-21)26-25(28)12-6-9-19-27-17-7-3-8-18-27/h4-5,10-11,13-16,20H,3,6-9,12,17-19H2,1-2H3,(H,26,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	240	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonist activity at rat alpha7 nAChR expressed in rat GH4C1 cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 17: 5247-58 (2009) Article DOI: 10.1016/j.bmc.2009.05.040 BindingDB Entry DOI: 10.7270/Q29K4B8H
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50300794 (5-Piperidin-1-yl-pentanoic acid(2',4'-difluorobiph...) Show SMILES Fc1ccc(c(F)c1)-c1ccc(NC(=O)CCCCN2CCCCC2)cc1 Show InChI InChI=1S/C22H26F2N2O/c23-18-9-12-20(21(24)16-18)17-7-10-19(11-8-17)25-22(27)6-2-5-15-26-13-3-1-4-14-26/h7-12,16H,1-6,13-15H2,(H,25,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	160	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonist activity at rat alpha7 nAChR expressed in rat GH4C1 cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 17: 5247-58 (2009) Article DOI: 10.1016/j.bmc.2009.05.040 BindingDB Entry DOI: 10.7270/Q29K4B8H
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50300795 (5-(4-Acetyl-[1,4]diazepan-1-yl)pentanoic acid(4-py...) Show SMILES CC(=O)N1CCCN(CCCCC(=O)Nc2ccc(cc2)-c2cccnc2)CC1 Show InChI InChI=1S/C23H30N4O2/c1-19(28)27-15-5-14-26(16-17-27)13-3-2-7-23(29)25-22-10-8-20(9-11-22)21-6-4-12-24-18-21/h4,6,8-12,18H,2-3,5,7,13-17H2,1H3,(H,25,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.66E+3	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonist activity at rat alpha7 nAChR expressed in rat GH4C1 cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 17: 5247-58 (2009) Article DOI: 10.1016/j.bmc.2009.05.040 BindingDB Entry DOI: 10.7270/Q29K4B8H
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50300798 (5-(4-Methylpiperazin-1-yl)pentanoic acid(4-pyridin...) Show SMILES CN1CCN(CCCCC(=O)Nc2ccc(cc2)-c2cccnc2)CC1 Show InChI InChI=1S/C21H28N4O/c1-24-13-15-25(16-14-24)12-3-2-6-21(26)23-20-9-7-18(8-10-20)19-5-4-11-22-17-19/h4-5,7-11,17H,2-3,6,12-16H2,1H3,(H,23,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	3.56E+3	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonist activity at rat alpha7 nAChR expressed in rat GH4C1 cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 17: 5247-58 (2009) Article DOI: 10.1016/j.bmc.2009.05.040 BindingDB Entry DOI: 10.7270/Q29K4B8H
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50300796 (5-Azepan-1-ylpentanoic acid(4-pyridin-3-yl-phenyl)...) Show SMILES O=C(CCCCN1CCCCCC1)Nc1ccc(cc1)-c1cccnc1 Show InChI InChI=1S/C22H29N3O/c26-22(9-3-6-17-25-15-4-1-2-5-16-25)24-21-12-10-19(11-13-21)20-8-7-14-23-18-20/h7-8,10-14,18H,1-6,9,15-17H2,(H,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	540	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonist activity at rat alpha7 nAChR expressed in rat GH4C1 cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 17: 5247-58 (2009) Article DOI: 10.1016/j.bmc.2009.05.040 BindingDB Entry DOI: 10.7270/Q29K4B8H
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50300797 (1-[4-(4-Pyridin-3-ylphenylcarbamoyl)butyl]piperidi...) Show SMILES CCN(CC)C(=O)C1CCCN(CCCCC(=O)Nc2ccc(cc2)-c2cccnc2)C1 Show InChI InChI=1S/C26H36N4O2/c1-3-30(4-2)26(32)23-10-8-18-29(20-23)17-6-5-11-25(31)28-24-14-12-21(13-15-24)22-9-7-16-27-19-22/h7,9,12-16,19,23H,3-6,8,10-11,17-18,20H2,1-2H3,(H,28,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonist activity at rat alpha7 nAChR expressed in rat GH4C1 cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 17: 5247-58 (2009) Article DOI: 10.1016/j.bmc.2009.05.040 BindingDB Entry DOI: 10.7270/Q29K4B8H
					More data for this Ligand-Target Pair