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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | TGF-beta receptor type-1 | ||
| Ligand | BDBM50301173 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_598612 (CHEMBL1048115) | ||
| IC50 | 34±n/a nM | ||
| Citation |  Ren, JX; Li, LL; Zou, J; Yang, L; Yang, JL; Yang, SY Pharmacophore modeling and virtual screening for the discovery of new transforming growth factor-beta type I receptor (ALK5) inhibitors. Eur J Med Chem44:4259-65 (2009) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| TGF-beta receptor type-1 | |||
| Name: | TGF-beta receptor type-1 | ||
| Synonyms: | ALK-5 | ALK5 | Activin A receptor type II-like protein kinase of 53kD | Activin receptor-like kinase 5 | SKR4 | Serine/threonine-protein kinase receptor R4 | TGF-beta receptor type I | TGF-beta type I receptor | TGFBR1 | TGFR-1 | TGFR1_HUMAN | TbetaR-I | Transforming growth factor-beta receptor type I | ||
| Type: | enzyme | ||
| Mol. Mass.: | 55968.24 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P36897 | ||
| Residue: | 503 | ||
| Sequence: |
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| BDBM50301173 | |||
| n/a | |||
| Name | BDBM50301173 | ||
| Synonyms: | 3-methoxy-N-(4-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yl)propanamide | CHEMBL565645 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H23N5O2 | ||
| Mol. Mass. | 413.4717 | ||
| SMILES | COCCC(=O)Nc1ccc2c(ccnc2c1)-c1c2CCCn2nc1-c1ccccn1 |(-.85,-11.96,;.5,-12.7,;1.82,-11.9,;3.17,-12.65,;4.49,-11.86,;4.46,-10.31,;5.84,-12.6,;7.16,-11.81,;7.14,-10.27,;8.45,-9.48,;9.79,-10.23,;11.11,-9.43,;12.46,-10.17,;12.49,-11.71,;11.16,-12.51,;9.81,-11.76,;8.5,-12.54,;11.09,-7.89,;9.82,-7,;8.28,-7.02,;7.79,-5.57,;9.02,-4.64,;10.28,-5.53,;11.82,-5.5,;12.32,-6.96,;13.65,-7.72,;13.66,-9.27,;15,-10.03,;16.33,-9.25,;16.32,-7.7,;14.98,-6.94,)| | ||
| Structure | 
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