Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | TGF-beta receptor type-1 | ||
| Ligand | BDBM50301179 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_598612 (CHEMBL1048115) | ||
| IC50 | 59±n/a nM | ||
| Citation |  Ren, JX; Li, LL; Zou, J; Yang, L; Yang, JL; Yang, SY Pharmacophore modeling and virtual screening for the discovery of new transforming growth factor-beta type I receptor (ALK5) inhibitors. Eur J Med Chem44:4259-65 (2009) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| TGF-beta receptor type-1 | |||
| Name: | TGF-beta receptor type-1 | ||
| Synonyms: | ALK-5 | ALK5 | Activin A receptor type II-like protein kinase of 53kD | Activin receptor-like kinase 5 | SKR4 | Serine/threonine-protein kinase receptor R4 | TGF-beta receptor type I | TGF-beta type I receptor | TGFBR1 | TGFR-1 | TGFR1_HUMAN | TbetaR-I | Transforming growth factor-beta receptor type I | ||
| Type: | enzyme | ||
| Mol. Mass.: | 55968.24 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P36897 | ||
| Residue: | 503 | ||
| Sequence: |
| ||
| BDBM50301179 | |||
| n/a | |||
| Name | BDBM50301179 | ||
| Synonyms: | 4-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-amine | CHEMBL585700 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H17N5 | ||
| Mol. Mass. | 327.3825 | ||
| SMILES | Nc1ccc2c(ccnc2c1)-c1c2CCCn2nc1-c1ccccn1 |(-7.41,-1.63,;-5.88,-1.79,;-4.97,-.54,;-3.45,-.7,;-2.83,-2.1,;-1.29,-2.26,;-.66,-3.66,;-1.56,-4.91,;-3.11,-4.75,;-3.73,-3.34,;-5.25,-3.18,;-.38,-1.02,;-.85,.45,;-2.11,1.34,;-1.64,2.81,;-.1,2.82,;.38,1.36,;1.64,.45,;1.16,-1.02,;2.06,-2.26,;1.43,-3.67,;2.33,-4.92,;3.87,-4.76,;4.5,-3.34,;3.59,-2.1,)| | ||
| Structure | 
| ||