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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | TGF-beta receptor type-1 | ||
| Ligand | BDBM50301180 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_598612 (CHEMBL1048115) | ||
| IC50 | 64±n/a nM | ||
| Citation |  Ren, JX; Li, LL; Zou, J; Yang, L; Yang, JL; Yang, SY Pharmacophore modeling and virtual screening for the discovery of new transforming growth factor-beta type I receptor (ALK5) inhibitors. Eur J Med Chem44:4259-65 (2009) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| TGF-beta receptor type-1 | |||
| Name: | TGF-beta receptor type-1 | ||
| Synonyms: | ALK-5 | ALK5 | Activin A receptor type II-like protein kinase of 53kD | Activin receptor-like kinase 5 | SKR4 | Serine/threonine-protein kinase receptor R4 | TGF-beta receptor type I | TGF-beta type I receptor | TGFBR1 | TGFR-1 | TGFR1_HUMAN | TbetaR-I | Transforming growth factor-beta receptor type I | ||
| Type: | enzyme | ||
| Mol. Mass.: | 55968.24 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P36897 | ||
| Residue: | 503 | ||
| Sequence: |
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| BDBM50301180 | |||
| n/a | |||
| Name | BDBM50301180 | ||
| Synonyms: | 2-(dimethylamino)-N-(4-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yl)acetamide | CHEMBL259821 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H24N6O | ||
| Mol. Mass. | 412.487 | ||
| SMILES | CN(C)CC(=O)Nc1ccc2c(ccnc2c1)-c1c2CCCn2nc1-c1ccccn1 |(7.23,2.09,;8.77,1.93,;9.67,3.18,;9.4,.52,;10.93,.37,;11.83,1.62,;11.56,-1.04,;13.1,-1.19,;14,.06,;15.53,-.11,;16.15,-1.51,;17.69,-1.67,;18.31,-3.07,;17.41,-4.32,;15.87,-4.16,;15.24,-2.75,;13.72,-2.59,;18.59,-.43,;18.12,1.04,;16.87,1.93,;17.33,3.4,;18.87,3.41,;19.36,1.95,;20.61,1.04,;20.13,-.43,;21.04,-1.67,;20.4,-3.08,;21.31,-4.33,;22.84,-4.17,;23.47,-2.75,;22.56,-1.51,)| | ||
| Structure | 
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