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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | TGF-beta receptor type-1 | ||
| Ligand | BDBM50301183 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_598612 (CHEMBL1048115) | ||
| IC50 | 79±n/a nM | ||
| Citation |  Ren, JX; Li, LL; Zou, J; Yang, L; Yang, JL; Yang, SY Pharmacophore modeling and virtual screening for the discovery of new transforming growth factor-beta type I receptor (ALK5) inhibitors. Eur J Med Chem44:4259-65 (2009) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| TGF-beta receptor type-1 | |||
| Name: | TGF-beta receptor type-1 | ||
| Synonyms: | ALK-5 | ALK5 | Activin A receptor type II-like protein kinase of 53kD | Activin receptor-like kinase 5 | SKR4 | Serine/threonine-protein kinase receptor R4 | TGF-beta receptor type I | TGF-beta type I receptor | TGFBR1 | TGFR-1 | TGFR1_HUMAN | TbetaR-I | Transforming growth factor-beta receptor type I | ||
| Type: | enzyme | ||
| Mol. Mass.: | 55968.24 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P36897 | ||
| Residue: | 503 | ||
| Sequence: |
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| BDBM50301183 | |||
| n/a | |||
| Name | BDBM50301183 | ||
| Synonyms: | 2-hydroxyethyl 4-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-ylcarbamate | CHEMBL566439 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H21N5O3 | ||
| Mol. Mass. | 415.4445 | ||
| SMILES | OCCOC(=O)Nc1ccc2c(ccnc2c1)-c1c2CCCn2nc1-c1ccccn1 |(27.2,-11.96,;27.83,-13.37,;29.37,-13.52,;30,-14.93,;31.53,-15.09,;32.44,-13.84,;32.17,-16.49,;33.7,-16.65,;34.6,-15.4,;36.13,-15.56,;36.75,-16.96,;38.29,-17.12,;38.91,-18.53,;38.01,-19.77,;36.47,-19.61,;35.85,-18.2,;34.33,-18.04,;39.19,-15.88,;38.72,-14.42,;37.47,-13.52,;37.93,-12.06,;39.47,-12.04,;39.96,-13.5,;41.22,-14.42,;40.74,-15.88,;41.64,-17.13,;41.01,-18.54,;41.91,-19.78,;43.44,-19.62,;44.07,-18.21,;43.16,-16.97,)| | ||
| Structure | 
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