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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | TGF-beta receptor type-1 | ||
| Ligand | BDBM50301184 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_598612 (CHEMBL1048115) | ||
| IC50 | 87±n/a nM | ||
| Citation |  Ren, JX; Li, LL; Zou, J; Yang, L; Yang, JL; Yang, SY Pharmacophore modeling and virtual screening for the discovery of new transforming growth factor-beta type I receptor (ALK5) inhibitors. Eur J Med Chem44:4259-65 (2009) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| TGF-beta receptor type-1 | |||
| Name: | TGF-beta receptor type-1 | ||
| Synonyms: | ALK-5 | ALK5 | Activin A receptor type II-like protein kinase of 53kD | Activin receptor-like kinase 5 | SKR4 | Serine/threonine-protein kinase receptor R4 | TGF-beta receptor type I | TGF-beta type I receptor | TGFBR1 | TGFR-1 | TGFR1_HUMAN | TbetaR-I | Transforming growth factor-beta receptor type I | ||
| Type: | enzyme | ||
| Mol. Mass.: | 55968.24 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P36897 | ||
| Residue: | 503 | ||
| Sequence: |
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| BDBM50301184 | |||
| n/a | |||
| Name | BDBM50301184 | ||
| Synonyms: | CHEMBL565815 | N-(4-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yl)acetamide | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H19N5O | ||
| Mol. Mass. | 369.4192 | ||
| SMILES | CC(=O)Nc1ccc2c(ccnc2c1)-c1c2CCCn2nc1-c1ccccn1 |(12.55,-29.52,;14.09,-29.68,;14.99,-28.43,;14.72,-31.09,;16.25,-31.24,;17.15,-29.99,;18.68,-30.15,;19.3,-31.55,;20.84,-31.72,;21.47,-33.12,;20.57,-34.37,;19.02,-34.21,;18.4,-32.79,;16.88,-32.64,;21.75,-30.48,;21.28,-29.01,;20.02,-28.12,;20.48,-26.65,;22.02,-26.63,;22.51,-28.09,;23.77,-29.01,;23.29,-30.48,;24.19,-31.72,;23.56,-33.13,;24.46,-34.38,;26,-34.22,;26.63,-32.8,;25.72,-31.56,)| | ||
| Structure | 
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