| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 1A |
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| Ligand | BDBM50301429 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_600323 (CHEMBL1038399) |
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| Ki | 14.6±n/a nM |
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| Citation |  Herold, F; Izbicki, L; Chodkowski, A; Dawidowski, M; Król, M; Kleps, J; Turlo, J; Wolska, I; Nowak, G; Stachowicz, K; Dybala, M; Siwek, A; Nowak, M; Pieniazek, E; Jaronczyk, M; Sylte, I; Mazurek, AP Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity: part 2. Eur J Med Chem44:4702-15 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 1A |
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| Name: | 5-hydroxytryptamine receptor 1A |
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| Synonyms: | 5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 46445.29 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Binding assays were performed using rat hippocampal membranes. |
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| Residue: | 422 |
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| Sequence: | MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGT
SLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGN
SKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RR
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| BDBM50301429 |
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| n/a |
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| Name | BDBM50301429 |
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| Synonyms: | 4-(4-Chloro-phenyl)-2-{4-[4-(5-methoxy-1H-indol-3-yl)-piperidin-1-yl]-butyl}-5,6,7,8-tetrahydro-pyrido[1,2-c]pyrimidine-1,3-dione | CHEMBL584114 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H37ClN4O3 |
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| Mol. Mass. | 561.114 |
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| SMILES | COc1ccc2[nH]cc(C3CCN(CCCCn4c(=O)c(-c5ccc(Cl)cc5)c5CCCCn5c4=O)CC3)c2c1 |
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| Structure | 
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