Ki Summary

Reaction Details

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Target

5-hydroxytryptamine receptor 1A

Ligand

BDBM50301445

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_600323 (CHEMBL1038399)

27.8±n/a nM

Citation

Herold, F; Izbicki, L; Chodkowski, A; Dawidowski, M; Król, M; Kleps, J; Turlo, J; Wolska, I; Nowak, G; Stachowicz, K; Dybala, M; Siwek, A; Nowak, M; Pieniazek, E; Jaronczyk, M; Sylte, I; Mazurek, AP Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity: part 2. Eur J Med Chem44:4702-15 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

5-hydroxytryptamine receptor 1A

Name:

5-hydroxytryptamine receptor 1A

Synonyms:

5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

46445.29

Organism:

Rattus norvegicus (rat)

Description:

Binding assays were performed using rat hippocampal membranes.

Residue:

422

Sequence:

MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGT
SLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGN
SKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RR

BDBM50301445

n/a

Name

BDBM50301445

Synonyms:

4-(2-Fluoro-phenyl)-2-{4-[4-(1H-indol-3-yl)-piperidin-1-yl]-butyl}-5,6,7,8-tetrahydro-pyrido[1,2-c]pyrimidine-1,3-dione | CHEMBL585714

Type

Small organic molecule

Emp. Form.

C31H35FN4O2

Mol. Mass.

514.6336

SMILES

Fc1ccccc1-c1c2CCCCn2c(=O)n(CCCCN2CCC(CC2)c2c[nH]c3ccccc23)c1=O |(-1.48,-44.82,;-2.82,-44.05,;-2.82,-42.5,;-4.16,-41.74,;-5.49,-42.51,;-5.49,-44.05,;-4.16,-44.82,;-4.16,-46.36,;-5.49,-47.13,;-6.81,-46.36,;-8.14,-47.12,;-8.15,-48.65,;-6.82,-49.43,;-5.5,-48.66,;-4.17,-49.44,;-4.18,-50.98,;-2.83,-48.68,;-1.5,-49.45,;-.16,-48.69,;1.17,-49.47,;2.5,-48.7,;3.83,-49.48,;3.81,-51.01,;5.14,-51.79,;6.48,-51.03,;6.49,-49.49,;5.16,-48.71,;7.8,-51.82,;7.96,-53.35,;9.46,-53.68,;10.24,-52.36,;11.74,-52.06,;12.24,-50.6,;11.21,-49.44,;9.71,-49.75,;9.22,-51.2,;-2.82,-47.13,;-1.49,-46.36,)|

Structure