| Reaction Details |
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 | Report a problem with these data |
| Target | Bifunctional epoxide hydrolase 2 |
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| Ligand | BDBM50301866 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_598451 (CHEMBL1044410) |
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| IC50 | 20±n/a nM |
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| Citation |  Shen, HC; Ding, FX; Deng, Q; Xu, S; Tong, X; Zhang, X; Chen, Y; Zhou, G; Pai, LY; Alonso-Galicia, M; Roy, S; Zhang, B; Tata, JR; Berger, JP; Colletti, SL A strategy of employing aminoheterocycles as amide mimics to identify novel, potent and bioavailable soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett19:5716-21 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bifunctional epoxide hydrolase 2 |
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| Name: | Bifunctional epoxide hydrolase 2 |
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| Synonyms: | Ephx2 | Epoxide hydrolase 2 | HYES_RAT |
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| Type: | PROTEIN |
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| Mol. Mass.: | 62337.15 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1465995 |
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| Residue: | 554 |
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| Sequence: | MALRVAAFDLDGVLALPSIAGVLRHTEEALALPRDFLLGAFQMKFPEGPTEQLMKGKITF
SQWVPLMDESCRKSSKACGASLPENFSISEIFSQAMAARSINRPMLQAAAALKKKGFTTC
IVTNNWLDDSDKRDILAQMMCELSQHFDFLIESCQVGMIKPEPQIYKFVLDTLKAKPNEV
VFLDDFGSNLKPARDMGMVTILVRDTASALRELEKVTGTQFPEAPLPVPCSPNDVSHGYV
TVKPGIRLHFVEMGSGPAICLCHGFPESWFSWRYQIPALAQAGFRVLAIDMKGYGDSSSP
PEIEEYAMELLCEEMVTFLNKLGIPQAVFIGHDWAGVLVWNMALFHPERVRAVASLNTPL
MPPNPEVSPMEVIRSIPVFNYQLYFQEPGVAEAELEKNMSRTFKSFFRTSDDMGLLTVNK
ATEMGGILVGTPEDPKVSKITTEEEIEYYIQQFKKSGFRGPLNWYRNTERNWKWSCKALG
RKILVPALMVTAEKDIVLRPEMSKNMENWIPFLKRGHIEDCGHWTQIEKPAEVNQILIKW
LKTEIQNPSVTSKI
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| BDBM50301866 |
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| n/a |
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| Name | BDBM50301866 |
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| Synonyms: | 6-(pyridin-3-yl)-N-(4-(trifluoromethyl)phenyl)benzo[d]isoxazol-3-amine | CHEMBL565941 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H12F3N3O |
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| Mol. Mass. | 355.3133 |
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| SMILES | FC(F)(F)c1ccc(Nc2noc3cc(ccc23)-c2cccnc2)cc1 |
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| Structure | 
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