| Reaction Details |
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 | Report a problem with these data |
| Target | Bifunctional epoxide hydrolase 2 |
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| Ligand | BDBM50302471 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_597622 (CHEMBL1039074) |
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| IC50 | 7±n/a nM |
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| Citation |  Taylor, SJ; Soleymanzadeh, F; Eldrup, AB; Farrow, NA; Muegge, I; Kukulka, A; Kabcenell, AK; De Lombaert, S Design and synthesis of substituted nicotinamides as inhibitors of soluble epoxide hydrolase. Bioorg Med Chem Lett19:5864-8 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bifunctional epoxide hydrolase 2 |
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| Name: | Bifunctional epoxide hydrolase 2 |
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| Synonyms: | Ephx2 | Epoxide hydrolase 2 | HYES_RAT |
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| Type: | PROTEIN |
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| Mol. Mass.: | 62337.15 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1465995 |
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| Residue: | 554 |
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| Sequence: | MALRVAAFDLDGVLALPSIAGVLRHTEEALALPRDFLLGAFQMKFPEGPTEQLMKGKITF
SQWVPLMDESCRKSSKACGASLPENFSISEIFSQAMAARSINRPMLQAAAALKKKGFTTC
IVTNNWLDDSDKRDILAQMMCELSQHFDFLIESCQVGMIKPEPQIYKFVLDTLKAKPNEV
VFLDDFGSNLKPARDMGMVTILVRDTASALRELEKVTGTQFPEAPLPVPCSPNDVSHGYV
TVKPGIRLHFVEMGSGPAICLCHGFPESWFSWRYQIPALAQAGFRVLAIDMKGYGDSSSP
PEIEEYAMELLCEEMVTFLNKLGIPQAVFIGHDWAGVLVWNMALFHPERVRAVASLNTPL
MPPNPEVSPMEVIRSIPVFNYQLYFQEPGVAEAELEKNMSRTFKSFFRTSDDMGLLTVNK
ATEMGGILVGTPEDPKVSKITTEEEIEYYIQQFKKSGFRGPLNWYRNTERNWKWSCKALG
RKILVPALMVTAEKDIVLRPEMSKNMENWIPFLKRGHIEDCGHWTQIEKPAEVNQILIKW
LKTEIQNPSVTSKI
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| BDBM50302471 |
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| n/a |
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| Name | BDBM50302471 |
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| Synonyms: | CHEMBL565841 | N-(4-chlorobenzyl)-6-(3,3,3-trifluoropropoxy)nicotinamide |
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| Type | Small organic molecule |
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| Emp. Form. | C16H14ClF3N2O2 |
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| Mol. Mass. | 358.743 |
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| SMILES | FC(F)(F)CCOc1ccc(cn1)C(=O)NCc1ccc(Cl)cc1 |
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| Structure | 
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