| Reaction Details |
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 | Report a problem with these data |
| Target | Bifunctional epoxide hydrolase 2 |
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| Ligand | BDBM50302465 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_597619 (CHEMBL1039071) |
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| IC50 | 31±n/a nM |
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| Citation |  Taylor, SJ; Soleymanzadeh, F; Eldrup, AB; Farrow, NA; Muegge, I; Kukulka, A; Kabcenell, AK; De Lombaert, S Design and synthesis of substituted nicotinamides as inhibitors of soluble epoxide hydrolase. Bioorg Med Chem Lett19:5864-8 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bifunctional epoxide hydrolase 2 |
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| Name: | Bifunctional epoxide hydrolase 2 |
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| Synonyms: | Cytosolic epoxide hydrolase 2 | EBifunctional epoxide hydrolase 2 | EPHX2 | Epoxide hydratase | HYES_HUMAN | Lipid-phosphate phosphatase | Soluble epoxide hydrolase (sEH) | epoxide hydrolase 2, cytoplasmic |
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| Type: | Enzyme |
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| Mol. Mass.: | 62613.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P34913 |
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| Residue: | 555 |
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| Sequence: | MTLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITL
SQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTA
ILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEV
VFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHG
YVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESS
APPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNT
PFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMH
KVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSL
GRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIK
WLDSDARNPPVVSKM
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| BDBM50302465 |
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| n/a |
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| Name | BDBM50302465 |
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| Synonyms: | CHEMBL566048 | N-(2-chloro-4-(N-methylsulfamoyl)benzyl)-6-(3,3,3-trifluoropropoxy)nicotinamide |
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| Type | Small organic molecule |
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| Emp. Form. | C17H17ClF3N3O4S |
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| Mol. Mass. | 451.848 |
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| SMILES | CNS(=O)(=O)c1ccc(CNC(=O)c2ccc(OCCC(F)(F)F)nc2)c(Cl)c1 |
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| Structure | 
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