| Reaction Details |
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 | Report a problem with these data |
| Target | Corticotropin-releasing factor receptor 1 |
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| Ligand | BDBM50302598 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_594612 (CHEMBL1037909) |
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| Ki | 43±n/a nM |
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| Citation |  Miller, DC; Klute, W; Calabrese, A; Brown, AD Optimising metabolic stability in lipophilic chemical space: the identification of a metabolically stable pyrazolopyrimidine CRF-1 receptor antagonist. Bioorg Med Chem Lett19:6144-7 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Corticotropin-releasing factor receptor 1 |
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| Name: | Corticotropin-releasing factor receptor 1 |
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| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 50744.31 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P34998 |
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| Residue: | 444 |
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| Sequence: | MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPA
GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
IINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLR
NIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGC
YLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYI
YQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFF
VNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARV
ARAMSIPTSPTRVSFHSIKQSTAV
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| BDBM50302598 |
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| n/a |
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| Name | BDBM50302598 |
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| Synonyms: | 1-(6-methoxy-2-methylpyridin-3-yl)-N-(2-methoxyethyl)-3,6-dimethyl-N-propyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine | CHEMBL568665 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H28N6O2 |
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| Mol. Mass. | 384.4753 |
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| SMILES | CCCN(CCOC)c1nc(C)nc2n(nc(C)c12)-c1ccc(OC)nc1C |
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| Structure | 
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