| Reaction Details |
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 | Report a problem with these data |
| Target | Neutrophil elastase |
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| Ligand | BDBM50303363 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_595760 (CHEMBL1045283) |
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| Kd | 9.5±n/a nM |
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| Citation |  Mulchande, J; Oliveira, R; Carrasco, M; Gouveia, L; Guedes, RC; Iley, J; Moreira, R 4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase. J Med Chem53:241-53 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutrophil elastase |
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| Name: | Neutrophil elastase |
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| Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
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| Type: | Enzyme |
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| Mol. Mass.: | 28532.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08246 |
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| Residue: | 267 |
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| Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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| BDBM50303363 |
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| n/a |
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| Name | BDBM50303363 |
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| Synonyms: | 2-(4-(3,3-Diethyl-2,4-dioxoazetidin-1-yl)benzylthio)benzo[d]-oxazole-6-carboxylic acid | CHEMBL568217 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H20N2O5S |
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| Mol. Mass. | 424.47 |
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| SMILES | CCC1(CC)C(=O)N(C1=O)c1ccc(CSc2nc3cc(ccc3o2)C(O)=O)cc1 |
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| Structure | 
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