| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Prostaglandin E2 receptor EP3 subtype |
|---|
| Ligand | BDBM50303675 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_596851 (CHEMBL1045310) |
|---|
| IC50 | 4±n/a nM |
|---|
| Citation |  Singh, J; Zeller, W; Zhou, N; Hategan, G; Mishra, RK; Polozov, A; Yu, P; Onua, E; Zhang, J; Ramírez, JL; Sigthorsson, G; Thorsteinnsdottir, M; Kiselyov, AS; Zembower, DE; Andrésson, T; Gurney, ME Structure-activity relationship studies leading to the identification of (2E)-3-[l-[(2,4-dichlorophenyl)methyl]-5-fluoro-3-methyl-lH-indol-7-yl]-N-[(4,5-dichloro-2-thienyl)sulfonyl]-2-propenamide (DG-041), a potent and selective prostanoid EP3 receptor antagonist, as a novel antiplatelet agent that J Med Chem53:18-36 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Prostaglandin E2 receptor EP3 subtype |
|---|
| Name: | Prostaglandin E2 receptor EP3 subtype |
|---|
| Synonyms: | PE2R3_MOUSE | PGE receptor, EP3 isoform alpha | Prostaglandin E2 receptor EP3 isoform alpha | Prostaglandin E3 | Prostanoid EP3 receptor | Ptger3 | Ptgerep3 |
|---|
| Type: | G-protein coupled receptor |
|---|
| Mol. Mass.: | 40092.50 |
|---|
| Organism: | Mus musculus (Mouse) |
|---|
| Description: | n/a |
|---|
| Residue: | 365 |
|---|
| Sequence: | MASMWAPEHSAEAHSNLSSTTDDCGSVSVAFPITMMVTGFVGNALAMLLVSRSYRRRESK
RKKSFLLCIGWLALTDLVGQLLTSPVVILVYLSQRRWEQLDPSGRLCTFFGLTMTVFGLS
SLLVASAMAVERALAIRAPHWYASHMKTRATPVLLGVWLSVLAFALLPVLGVGRYSVQWP
GTWCFISTGPAGNETDPAREPGSVAFASAFACLGLLALVVTFACNLATIKALVSRCRAKA
AVSQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQMSVEQCKTQMGKEKE
CNSFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRDHTNYASSSTSLPCPGSSALMWS
DQLER
|
|
|
|---|
| BDBM50303675 |
|---|
| n/a |
|---|
| Name | BDBM50303675 |
|---|
| Synonyms: | 2-(1-(2,4-dichlorobenzyl)-1H-benzo[d]imidazol-7-yloxy)-N-(4,5-dichlorothiophen-2-ylsulfonyl)acetamide | CHEMBL565992 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H13Cl4N3O4S2 |
|---|
| Mol. Mass. | 565.277 |
|---|
| SMILES | Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2ncn(Cc3ccc(Cl)cc3Cl)c12 |
|---|
| Structure | 
|
|---|
Search and Browse
