| Reaction Details |
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 | Report a problem with these data |
| Target | Neuroendocrine convertase 1 |
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| Ligand | BDBM50303776 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_597567 (CHEMBL1049704) |
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| Ki | 3.7±n/a nM |
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| Citation |  Becker, GL; Sielaff, F; Than, ME; Lindberg, I; Routhier, S; Day, R; Lu, Y; Garten, W; Steinmetzer, T Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics. J Med Chem53:1067-75 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuroendocrine convertase 1 |
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| Name: | Neuroendocrine convertase 1 |
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| Synonyms: | NEC1 | NEC1_HUMAN | PCSK1 | Prohormone convertase 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 84143.04 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_597567 |
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| Residue: | 753 |
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| Sequence: | MERRAWSLQCTAFVLFCAWCALNSAKAKRQFVNEWAAEIPGGPEAASAIAEELGYDLLGQ
IGSLENHYLFKHKNHPRRSRRSAFHITKRLSDDDRVIWAEQQYEKERSKRSALRDSALNL
FNDPMWNQQWYLQDTRMTAALPKLDLHVIPVWQKGITGKGVVITVLDDGLEWNHTDIYAN
YDPEASYDFNDNDHDPFPRYDPTNENKHGTRCAGEIAMQANNHKCGVGVAYNSKVGGIRM
LDGIVTDAIEASSIGFNPGHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGVKQGRQGKG
SIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATSYSSGDY
TDQRITSADLHNDCTETHTGTSASAPLAAGIFALALEANPNLTWRDMQHLVVWTSEYDPL
ANNPGWKKNGAGLMVNSRFGFGLLNAKALVDLADPRTWRSVPEKKECVVKDNDFEPRALK
ANGEVIIEIPTRACEGQENAIKSLEHVQFEATIEYSRRGDLHVTLTSAAGTSTVLLAERE
RDTSPNGFKNWDFMSVHTWGENPIGTWTLRITDMSGRIQNEGRIVNWKLILHGTSSQPEH
MKQPRVYTSYNTVQNDRRGVEKMVDPGEEQPTQENPKENTLVSKSPSSSSVGGRRDELEE
GAPSQAMLRLLQSAFSKNSPPKQSPKKSPSAKLNIPYENFYEALEKLNKPSQLKDSEDSL
YNDYVDVFYNTKPYKHRDDRLLQALVDILNEEN
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| BDBM50303776 |
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| n/a |
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| Name | BDBM50303776 |
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| Synonyms: | CHEMBL568525 | N-((6S,9S,12S)-1,17-diamino-6-(4-carbamimidoylbenzylcarbamoyl)-1,17-diimino-9-isopropyl-8,11-dioxo-2,7,10,16-tetraazaheptadecan-12-yl)decanamide |
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| Type | Small organic molecule |
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| Emp. Form. | C35H62N12O4 |
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| Mol. Mass. | 714.9448 |
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| SMILES | [#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6]-c1ccc(cc1)-[#6](-[#7])=[#7] |r| |
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| Structure | 
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