Reaction Details |
| Report a problem with these data |
Target | Sodium- and chloride-dependent GABA transporter 1 |
---|
Ligand | BDBM50304262 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_605767 (CHEMBL1073263) |
---|
IC50 | 5810±n/a nM |
---|
Citation | Zhuang, W; Zhao, X; Zhao, G; Guo, L; Lian, Y; Zhou, J; Fang, D Synthesis and biological evaluation of 4-fluoroproline and 4-fluoropyrrolidine-2-acetic acid derivatives as new GABA uptake inhibitors. Bioorg Med Chem17:6540-6 (2009) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Sodium- and chloride-dependent GABA transporter 1 |
---|
Name: | Sodium- and chloride-dependent GABA transporter 1 |
Synonyms: | GABA transporter | GABA transporter 1 | Gabt1 | Gat-1 | Gat1 | SC6A1_MOUSE | Slc6a1 |
Type: | PROTEIN |
Mol. Mass.: | 67006.26 |
Organism: | Mus musculus |
Description: | ChEMBL_788602 |
Residue: | 599 |
Sequence: | MATDNSKVADGQISTEVSEAPVASDKPKTLVVKVQKKAGDLPDRDTWKGRFDFLMSCVGY
AIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAP
MFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSLV
NTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWVLVYFCIWKGVGWTGKVV
YFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGL
GSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASG
PGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRR
ELFIAAVCIVSYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRF
YDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFLFSAVQMTPLTMGSYVFPKWGQGVGWLM
ALSSMVLIPGYMAYMFLTLKGSLKQRLQVMIQPSEDIVRPENGPEQPQAGSSASKEAYI
|
|
|
BDBM50304262 |
---|
n/a |
---|
Name | BDBM50304262 |
Synonyms: | 2-((2S,4S)-1-(4,4-diphenylbut-3-enyl)-4-fluoropyrrolidin-2-yl)acetic acid hydrochloride | CHEMBL611943 |
Type | Small organic molecule |
Emp. Form. | C22H24FNO2 |
Mol. Mass. | 353.4299 |
SMILES | [#8]-[#6](=O)-[#6]-[#6@H]-1-[#6]-[#6@H](F)-[#6]-[#7]-1-[#6]-[#6]\[#6]=[#6](\c1ccccc1)-c1ccccc1 |r| |
Structure |
|