Ki Summary

Reaction Details

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Target

Neuropeptide Y receptor type 5

Ligand

BDBM50304302

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_606463 (CHEMBL1074028)

IC50

2.5±n/a nM

Citation

Haga, Y; Sakamoto, T; Shibata, T; Nonoshita, K; Ishikawa, M; Suga, T; Takahashi, H; Takahashi, T; Takahashi, H; Ando, M; Murai, T; Gomori, A; Oda, Z; Kitazawa, H; Mitobe, Y; Kanesaka, M; Ohe, T; Iwaasa, H; Ishii, Y; Ishihara, A; Kanatani, A; Fukami, T Discovery of trans-N-[1-(2-fluorophenyl)-3-pyrazolyl]-3-oxospiro[6-azaisobenzofuran-1(3H),1'-cyclohexane]-4'-carboxamide, a potent and orally active neuropeptide Y Y5 receptor antagonist. Bioorg Med Chem17:6971-82 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Neuropeptide Y receptor type 5

Name:

Neuropeptide Y receptor type 5

Synonyms:

NPY-Y5 | NPY5R_RAT | Neuropeptide Y receptor type 5 | Npy5r | Npyr5

Type:

Enzyme Catalytic Domain

Mol. Mass.:

50435.58

Organism:

Rat 6B

Description:

NPY-Y5 NPY5R Rat 6B::Q63634

Residue:

445

Sequence:

MEFKLEEHFNKTFVTENNTAAARNAAFPAWEDYRGSVDDLQYFLIGLYTFVSLLGFMGNL
LILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFL
QCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSL
VELKETFGSALLSSKYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISC
GLSHKENRLEENEMINLTLQPSKKSRNQAKTPSTQKWSYSFIRKHRRRYSKKTACVLPAP
AGPSQGKHLAVPENPASVRSQLSPSSKVIPGVPICFEVKPEESSDAHEMRVKRSITRIKK
RSRSVFYRLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLN
PILYGFLNNGIKADLRALIHCLHMS

BDBM50304302

n/a

Name

BDBM50304302

Synonyms:

3'-oxo-N-(5-phenylpyrazin-2-yl)-3'H-spiro[cyclohexane-1,1'-isobenzofuran]-4-carboxamide | CHEMBL594156

Type

Small organic molecule

Emp. Form.

C24H21N3O3

Mol. Mass.

399.4418

SMILES

n/a

Structure