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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Neuropeptide Y receptor type 5 | ||
| Ligand | BDBM50301644 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_606453 (CHEMBL1074018) | ||
| IC50 | 2.1±n/a nM | ||
| Citation |  Haga, Y; Sakamoto, T; Shibata, T; Nonoshita, K; Ishikawa, M; Suga, T; Takahashi, H; Takahashi, T; Takahashi, H; Ando, M; Murai, T; Gomori, A; Oda, Z; Kitazawa, H; Mitobe, Y; Kanesaka, M; Ohe, T; Iwaasa, H; Ishii, Y; Ishihara, A; Kanatani, A; Fukami, T Discovery of trans-N-[1-(2-fluorophenyl)-3-pyrazolyl]-3-oxospiro[6-azaisobenzofuran-1(3H),1'-cyclohexane]-4'-carboxamide, a potent and orally active neuropeptide Y Y5 receptor antagonist. Bioorg Med Chem17:6971-82 (2009) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Neuropeptide Y receptor type 5 | |||
| Name: | Neuropeptide Y receptor type 5 | ||
| Synonyms: | NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50746.64 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q15761 | ||
| Residue: | 445 | ||
| Sequence: |
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| BDBM50301644 | |||
| n/a | |||
| Name | BDBM50301644 | ||
| Synonyms: | CHEMBL568144 | trans-3-Oxo-N-(5-phenylpyrimidin-2-yl)-3H-spiro[4-aza-2-benzofuran-1,1'-cyclohexane]-4'-carboxamide | trans-7'-oxo-N-(5-phenylpyrimidin-2-yl)-7'H-spiro[cyclohexane-1,5'-furo[3,4-b]pyridine]-4-carboxamide | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H20N4O3 | ||
| Mol. Mass. | 400.4299 | ||
| SMILES | O=C(Nc1ncc(cn1)-c1ccccc1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ncccc21 |r,wU:18.23,wD:15.16,(27.63,5.75,;28.4,4.41,;29.94,4.41,;30.71,3.08,;29.93,1.75,;30.7,.41,;32.24,.41,;33.01,1.75,;32.24,3.08,;33.01,-.92,;32.24,-2.25,;33,-3.58,;34.55,-3.58,;35.32,-2.24,;34.54,-.91,;27.63,3.08,;26.09,3.08,;25.31,1.75,;26.09,.42,;27.63,.42,;28.39,1.75,;27.01,-.84,;26.09,-2.09,;26.57,-3.56,;24.62,-1.61,;23.29,-2.39,;21.95,-1.61,;21.95,-.07,;23.28,.7,;24.62,-.06,)| | ||
| Structure | 
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