Ki Summary

Reaction Details

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Target

Neuropeptide Y receptor type 5

Ligand

BDBM50304305

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_606453 (CHEMBL1074018)

IC50

2.8±n/a nM

Citation

Haga, Y; Sakamoto, T; Shibata, T; Nonoshita, K; Ishikawa, M; Suga, T; Takahashi, H; Takahashi, T; Takahashi, H; Ando, M; Murai, T; Gomori, A; Oda, Z; Kitazawa, H; Mitobe, Y; Kanesaka, M; Ohe, T; Iwaasa, H; Ishii, Y; Ishihara, A; Kanatani, A; Fukami, T Discovery of trans-N-[1-(2-fluorophenyl)-3-pyrazolyl]-3-oxospiro[6-azaisobenzofuran-1(3H),1'-cyclohexane]-4'-carboxamide, a potent and orally active neuropeptide Y Y5 receptor antagonist. Bioorg Med Chem17:6971-82 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Neuropeptide Y receptor type 5

Name:

Neuropeptide Y receptor type 5

Synonyms:

Type:

Enzyme

Mol. Mass.:

50746.64

Organism:

Homo sapiens (Human)

Description:

Q15761

Residue:

445

Sequence:

MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNL
LILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFL
QCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSL
VELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISC
GLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAP
ERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIK
KRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCL
NPILYGFLNNGIKADLVSLIHCLHM

BDBM50304305

n/a

Name

BDBM50304305

Synonyms:

CHEMBL607192 | trans-3-Oxo-N-(5-phenylisoxazol-3-yl)-3H-spiro[4-aza-2-benzofuran-1,1'-cyclohexane]-4'-carboxamide

Type

Small organic molecule

Emp. Form.

C22H19N3O4

Mol. Mass.

389.404

SMILES

O=C(Nc1cc(on1)-c1ccccc1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ncccc21 |r,wU:17.22,wD:14.15,(-4.45,-8.24,;-3.68,-9.57,;-2.14,-9.57,;-1.26,-10.84,;-1.77,-12.3,;-.55,-13.24,;.72,-12.36,;.28,-10.88,;-.58,-14.78,;-1.93,-15.51,;-1.97,-17.04,;-.65,-17.85,;.7,-17.1,;.73,-15.56,;-4.45,-10.9,;-5.99,-10.9,;-6.76,-12.24,;-5.99,-13.56,;-4.45,-13.56,;-3.68,-12.24,;-5.07,-14.82,;-5.98,-16.08,;-5.51,-17.54,;-7.46,-15.6,;-8.79,-16.37,;-10.12,-15.6,;-10.12,-14.05,;-8.79,-13.28,;-7.46,-14.05,)|

Structure