Ki Summary

Reaction Details

Report a problem with these data

Target

Neuropeptide Y receptor type 5

Ligand

BDBM50304309

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_606453 (CHEMBL1074018)

IC50

2.2±n/a nM

Citation

Haga, Y; Sakamoto, T; Shibata, T; Nonoshita, K; Ishikawa, M; Suga, T; Takahashi, H; Takahashi, T; Takahashi, H; Ando, M; Murai, T; Gomori, A; Oda, Z; Kitazawa, H; Mitobe, Y; Kanesaka, M; Ohe, T; Iwaasa, H; Ishii, Y; Ishihara, A; Kanatani, A; Fukami, T Discovery of trans-N-[1-(2-fluorophenyl)-3-pyrazolyl]-3-oxospiro[6-azaisobenzofuran-1(3H),1'-cyclohexane]-4'-carboxamide, a potent and orally active neuropeptide Y Y5 receptor antagonist. Bioorg Med Chem17:6971-82 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Neuropeptide Y receptor type 5

Name:

Neuropeptide Y receptor type 5

Synonyms:

Type:

Enzyme

Mol. Mass.:

50746.64

Organism:

Homo sapiens (Human)

Description:

Q15761

Residue:

445

Sequence:

MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNL
LILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFL
QCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSL
VELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISC
GLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAP
ERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIK
KRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCL
NPILYGFLNNGIKADLVSLIHCLHM

BDBM50304309

n/a

Name

BDBM50304309

Synonyms:

CHEMBL607144 | trans-3-Oxo-N-(5-phenylpyrazin-2-yl)-3H-spiro[6-aza-2-benzofuran-1,1'-cyclohexane]-4'-carboxamide

Type

Small organic molecule

Emp. Form.

C23H20N4O3

Mol. Mass.

400.4299

SMILES

O=C(Nc1cnc(cn1)-c1ccccc1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccncc21 |r,wU:18.23,wD:15.16,(12.25,-35.6,;13.01,-36.93,;14.55,-36.94,;15.39,-38.23,;14.68,-39.59,;15.52,-40.89,;17.06,-40.81,;17.76,-39.43,;16.92,-38.14,;17.9,-42.1,;17.19,-43.47,;18.03,-44.76,;19.57,-44.69,;20.27,-43.31,;19.43,-42.02,;12.24,-38.27,;10.7,-38.27,;9.93,-39.6,;10.7,-40.93,;12.24,-40.93,;13.01,-39.6,;11.62,-42.18,;10.71,-43.44,;11.19,-44.9,;9.23,-42.96,;7.9,-43.73,;6.57,-42.96,;6.57,-41.42,;7.9,-40.65,;9.23,-41.41,)|

Structure