Ki Summary

Reaction Details

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Target

Neuropeptide Y receptor type 5

Ligand

BDBM50304310

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_606453 (CHEMBL1074018)

IC50

2.1±n/a nM

Citation

Haga, Y; Sakamoto, T; Shibata, T; Nonoshita, K; Ishikawa, M; Suga, T; Takahashi, H; Takahashi, T; Takahashi, H; Ando, M; Murai, T; Gomori, A; Oda, Z; Kitazawa, H; Mitobe, Y; Kanesaka, M; Ohe, T; Iwaasa, H; Ishii, Y; Ishihara, A; Kanatani, A; Fukami, T Discovery of trans-N-[1-(2-fluorophenyl)-3-pyrazolyl]-3-oxospiro[6-azaisobenzofuran-1(3H),1'-cyclohexane]-4'-carboxamide, a potent and orally active neuropeptide Y Y5 receptor antagonist. Bioorg Med Chem17:6971-82 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Neuropeptide Y receptor type 5

Name:

Neuropeptide Y receptor type 5

Synonyms:

Type:

Enzyme

Mol. Mass.:

50746.64

Organism:

Homo sapiens (Human)

Description:

Q15761

Residue:

445

Sequence:

MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNL
LILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFL
QCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSL
VELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISC
GLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAP
ERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIK
KRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCL
NPILYGFLNNGIKADLVSLIHCLHM

BDBM50304310

n/a

Name

BDBM50304310

Synonyms:

CHEMBL596264 | trans-3-Oxo-N-(5-phenylisoxazol-3-yl)-3H-spiro[6-aza-2-benzofuran-1,1'-cyclohexane]-4'-carboxamide

Type

Small organic molecule

Emp. Form.

C22H19N3O4

Mol. Mass.

389.404

SMILES

O=C(Nc1cc(on1)-c1ccccc1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccncc21 |r,wU:17.22,wD:14.15,(-3.73,5.98,;-2.96,4.65,;-1.42,4.65,;-.52,3.4,;-1,1.93,;.24,1.03,;1.49,1.93,;1.01,3.39,;.24,-.51,;-1.1,-1.28,;-1.1,-2.82,;.23,-3.59,;1.57,-2.81,;1.57,-1.28,;-3.73,3.31,;-5.27,3.31,;-6.05,1.98,;-5.27,.65,;-3.73,.65,;-2.97,1.98,;-4.35,-.6,;-5.27,-1.86,;-4.79,-3.32,;-6.74,-1.38,;-8.07,-2.15,;-9.41,-1.38,;-9.41,.16,;-8.08,.93,;-6.74,.17,)|

Structure