Ki Summary

Reaction Details

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Target

Neuropeptide Y receptor type 5

Ligand

BDBM50304301

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_606453 (CHEMBL1074018)

IC50

0.92±n/a nM

Citation

Haga, Y; Sakamoto, T; Shibata, T; Nonoshita, K; Ishikawa, M; Suga, T; Takahashi, H; Takahashi, T; Takahashi, H; Ando, M; Murai, T; Gomori, A; Oda, Z; Kitazawa, H; Mitobe, Y; Kanesaka, M; Ohe, T; Iwaasa, H; Ishii, Y; Ishihara, A; Kanatani, A; Fukami, T Discovery of trans-N-[1-(2-fluorophenyl)-3-pyrazolyl]-3-oxospiro[6-azaisobenzofuran-1(3H),1'-cyclohexane]-4'-carboxamide, a potent and orally active neuropeptide Y Y5 receptor antagonist. Bioorg Med Chem17:6971-82 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Neuropeptide Y receptor type 5

Name:

Neuropeptide Y receptor type 5

Synonyms:

Type:

Enzyme

Mol. Mass.:

50746.64

Organism:

Homo sapiens (Human)

Description:

Q15761

Residue:

445

Sequence:

MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNL
LILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFL
QCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSL
VELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISC
GLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAP
ERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIK
KRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCL
NPILYGFLNNGIKADLVSLIHCLHM

BDBM50304301

n/a

Name

BDBM50304301

Synonyms:

CHEMBL595790 | trans-N-[1-(3-Fluorophenyl)-1H-pyrazol-3-yl]-3-oxo-3Hspiro[6-aza-2-benzofuran-1,1'-cyclohexane]-4'-carboxamide

Type

Small organic molecule

Emp. Form.

C22H19FN4O3

Mol. Mass.

406.4097

SMILES

Fc1ccc(cc1)-n1ccc(NC(=O)[C@H]2CC[C@@]3(CC2)OC(=O)c2ccncc32)n1 |r,wU:17.21,wD:14.14,(.68,-45.87,;.68,-44.33,;-.66,-43.55,;-.65,-42.02,;.68,-41.25,;2.01,-42.01,;2.02,-43.55,;.68,-39.72,;1.93,-38.81,;1.45,-37.35,;-.09,-37.35,;-.99,-36.1,;-2.53,-36.1,;-3.3,-34.77,;-3.31,-37.43,;-4.85,-37.43,;-5.62,-38.77,;-4.85,-40.09,;-3.31,-40.09,;-2.54,-38.77,;-3.93,-41.35,;-4.84,-42.61,;-4.36,-44.07,;-6.31,-42.13,;-7.65,-42.9,;-8.98,-42.13,;-8.98,-40.58,;-7.65,-39.81,;-6.31,-40.58,;-.56,-38.81,)|

Structure