| Reaction Details |
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 | Report a problem with these data |
| Target | Vitamin D3 receptor |
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| Ligand | BDBM50304584 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_606222 (CHEMBL1067955) |
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| EC50 | 0.2±n/a nM |
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| Citation |  Barycki, R; Sicinski, RR; Plum, LA; Grzywacz, P; Clagett-Dame, M; Deluca, HF Removal of the 20-methyl group from 2-methylene-19-nor-(20S)-1alpha,25-dihydroxyvitamin D(3) (2MD) selectively eliminates bone calcium mobilization activity. Bioorg Med Chem17:7658-69 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Vitamin D3 receptor |
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| Name: | Vitamin D3 receptor |
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| Synonyms: | Nr1i1 | VDR_RAT | Vdr | Vitamin D receptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47811.07 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1505946 |
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| Residue: | 423 |
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| Sequence: | MEATAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTC
PFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMIMKRKEEEALKDSL
RPKLSEEQQHIIAILLDAHHKTYDPTYADFRDFRPPVRMDGSTGSYSPRPTLSFSGNSSS
SSSDLYTTSLDMMEPSGFSNLDLNGEDSDDPSVTLDLSPLSMLPHLADLVSYSIQKVIGF
AKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQSFTMDDMSWDCGSQDYKYDVTDVSKAG
HTLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAKLVEAIQDRLSNTLQ
TYIRCRHPPPGSHQLYAKMIQKLADLRSLNEEHSKQYRSLSFQPENSMKLTPLVLEVFGN
EIS
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| BDBM50304584 |
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| n/a |
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| Name | BDBM50304584 |
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| Synonyms: | 1alpha,25-Dihydroxy-2-methylene-19,21-dinorvitamin D3 | CHEMBL607373 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H42O3 |
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| Mol. Mass. | 402.6099 |
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| SMILES | [#6]C([#6])([#8])[#6]-[#6]-[#6]-[#6]-[#6@H]1-[#6]-[#6]-[#6@H]2\[#6](-[#6]-[#6]-[#6][C@]12[#6])=[#6]\[#6]=[#6]-1\[#6]-[#6@@H](-[#8])-[#6](=[#6])-[#6@H](-[#8])-[#6]-1 |r| |
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| Structure | 
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