| Reaction Details |
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 | Report a problem with these data |
| Target | Hypoxia-inducible factor 1-alpha inhibitor |
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| Ligand | BDBM50304612 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_606822 (CHEMBL1068586) |
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| IC50 | 36200±n/a nM |
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| Citation |  Ko, S; Lee, MK; Shin, D; Park, H Structure-based virtual screening approach to the discovery of novel inhibitors of factor-inhibiting HIF-1: identification of new chelating groups for the active-site ferrous ion. Bioorg Med Chem17:7769-74 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hypoxia-inducible factor 1-alpha inhibitor |
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| Name: | Hypoxia-inducible factor 1-alpha inhibitor |
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| Synonyms: | FIH1 | HIF1AN | HIF1N_HUMAN | Hypoxia-inducible factor 1 (FIH) | Hypoxia-inducible factor 1-alpha inhibitor |
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| Type: | Enzyme |
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| Mol. Mass.: | 40278.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NWT6 |
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| Residue: | 349 |
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| Sequence: | MAATAAEAVASGSGEPREEAGALGPAWDESQLRSYSFPTRPIPRLSQSDPRAEELIENEE
PVVLTDTNLVYPALKWDLEYLQENIGNGDFSVYSASTHKFLYYDEKKMANFQNFKPRSNR
EEMKFHEFVEKLQDIQQRGGEERLYLQQTLNDTVGRKIVMDFLGFNWNWINKQQGKRGWG
QLTSNLLLIGMEGNVTPAHYDEQQNFFAQIKGYKRCILFPPDQFECLYPYPVHHPCDRQS
QVDFDNPDYERFPNFQNVVGYETVVGPGDVLYIPMYWWHHIESLLNGGITITVNFWYKGA
PTPKRIEYPLKAHQKVAIMRNIEKMLGEALGNPQEVGPLLNTMIKGRYN
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| BDBM50304612 |
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| n/a |
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| Name | BDBM50304612 |
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| Synonyms: | 2-(5-((3-(4-(ethylthio)phenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid | CHEMBL596586 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H19N3O3S3 |
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| Mol. Mass. | 481.61 |
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| SMILES | CCSc1ccc(cc1)-c1nn(cc1\C=C1\SC(=S)N(CC(O)=O)C1=O)-c1ccccc1 |
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| Structure | 
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