| Reaction Details |
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 | Report a problem with these data |
| Target | Glutamate carboxypeptidase 2 |
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| Ligand | BDBM50304714 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_605564 (CHEMBL1067318) |
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| Ki | 153±n/a nM |
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| Citation |  Wang, H; Byun, Y; Barinka, C; Pullambhatla, M; Bhang, HE; Fox, JJ; Lubkowski, J; Mease, RC; Pomper, MG Bioisosterism of urea-based GCPII inhibitors: Synthesis and structure-activity relationship studies. Bioorg Med Chem Lett20:392-7 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutamate carboxypeptidase 2 |
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| Name: | Glutamate carboxypeptidase 2 |
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| Synonyms: | FGCP | FOLH | FOLH1 | FOLH1_HUMAN | Folate hydrolase 1 | Folylpoly-gamma-glutamate carboxypeptidase | Glutamate carboxypeptidase 2 | Glutamate carboxypeptidase II | Membrane glutamate carboxypeptidase | N-acetylated-alpha-linked acidic dipeptidase I | NAALAD1 | NAALADase I | PSM | PSMA | Prostate-specific membrane antigen | Pteroylpoly-gamma-glutamate carboxypeptidase | mGCP |
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| Type: | PROTEIN |
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| Mol. Mass.: | 84333.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1497035 |
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| Residue: | 750 |
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| Sequence: | MWNLLHETDSAVATARRPRWLCAGALVLAGGFFLLGFLFGWFIKSSNEATNITPKHNMKA
FLDELKAENIKKFLYNFTQIPHLAGTEQNFQLAKQIQSQWKEFGLDSVELAHYDVLLSYP
NKTHPNYISIINEDGNEIFNTSLFEPPPPGYENVSDIVPPFSAFSPQGMPEGDLVYVNYA
RTEDFFKLERDMKINCSGKIVIARYGKVFRGNKVKNAQLAGAKGVILYSDPADYFAPGVK
SYPDGWNLPGGGVQRGNILNLNGAGDPLTPGYPANEYAYRRGIAEAVGLPSIPVHPIGYY
DAQKLLEKMGGSAPPDSSWRGSLKVPYNVGPGFTGNFSTQKVKMHIHSTNEVTRIYNVIG
TLRGAVEPDRYVILGGHRDSWVFGGIDPQSGAAVVHEIVRSFGTLKKEGWRPRRTILFAS
WDAEEFGLLGSTEWAEENSRLLQERGVAYINADSSIEGNYTLRVDCTPLMYSLVHNLTKE
LKSPDEGFEGKSLYESWTKKSPSPEFSGMPRISKLGSGNDFEVFFQRLGIASGRARYTKN
WETNKFSGYPLYHSVYETYELVEKFYDPMFKYHLTVAQVRGGMVFELANSIVLPFDCRDY
AVVLRKYADKIYSISMKHPQEMKTYSVSFDSLFSAVKNFTEIASKFSERLQDFDKSNPIV
LRMMNDQLMFLERAFIDPLGLPDRPFYRHVIYAPSSHNKYAGESFPGIYDALFDIESKVD
PSKAWGEVKRQIYVAAFTVQAAAETLSEVA
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| BDBM50304714 |
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| n/a |
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| Name | BDBM50304714 |
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| Synonyms: | 2-(4-Hydroxy-3-methoxyphenyl)-2-(3-((S)-1-methoxy-4-methyl-1-oxopentan-2-yl)ureido)acetic acid | CHEMBL595741 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H24N2O7 |
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| Mol. Mass. | 368.3817 |
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| SMILES | COC(=O)[C@H](CC(C)C)NC(=O)NC(C(O)=O)c1ccc(O)c(OC)c1 |r| |
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| Structure | 
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